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In the last 80 years, male semen analysis parameters have shown a significant decline for unknown reasons, speculated to be caused by pollutants. No studies examined the relationship between human MP exposure and male infertility. In this article, we reviewed the relevant animal experimental research literature in recent years and calculated that the minimum human equivalent dose of MPs leading to abnormal male semen quality is 0.016 mg\/kg\/d. The literature comparison found that MP exposure in Japan and South Korea was close to this value. These results suggest that MPs can affect male semen quality and that MPs may significantly impact male fertility.<\/jats:p>","DOI":"10.1177\/15579883221096549","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T05:23:47Z","timestamp":1653369827000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":84,"title":["Microplastics May Be a Significant Cause of Male Infertility"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1426-0092","authenticated-orcid":false,"given":"Chenming","family":"Zhang","sequence":"first","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshe","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixue","family":"Sun","sequence":"additional","affiliation":[{"name":"Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulong","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"bibr1-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.10.039"},{"key":"bibr2-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114158"},{"key":"bibr3-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152665"},{"key":"bibr4-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6854.609"},{"key":"bibr5-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.11.035"},{"key":"bibr6-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz028"},{"key":"bibr7-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b01517"},{"key":"bibr8-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124644"},{"key":"bibr9-15579883221096549","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.05.39"},{"key":"bibr10-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2014.01.005"},{"key":"bibr11-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.06.039"},{"key":"bibr12-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2018.10.009"},{"key":"bibr13-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.109882"},{"key":"bibr14-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124028"},{"key":"bibr15-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.142042"},{"key":"bibr16-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112803"},{"key":"bibr17-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.146264"},{"key":"bibr18-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64464-9"},{"key":"bibr19-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1177\/15593258211019882"},{"key":"bibr20-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv016"},{"key":"bibr21-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260352"},{"key":"bibr22-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123430"},{"key":"bibr23-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.08.353"},{"key":"bibr24-15579883221096549","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180274"},{"key":"bibr25-15579883221096549","unstructured":"Lassen C., Foss Hansen S., Magnusson K., Nor\u00e9n F., Bloch Hartmann N., Rehne Jensen P., Gissel Nielsen T., Brinch A. 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