{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:46:54Z","timestamp":1777855614554,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Acmella oleracea (L.) R. K. Jansen (Asteraceae) is a plant species widely used in traditional Amazonian medicine to treat sexual dysfunction. The use of this plant has gained popularity because of its sensory properties, such as a tingling sensation. In this study on patients with premature ejaculation, we evaluated the clinical action of a nano-formulation containing an ethanolic extract of A. oleracea inflorescences. Major constituents in the extracts were identified based on gas chromatographic analysis. Participants used a spray preparation based on the A. oleracea extract for 12 weeks, during which they were instructed to apply the product 5 min prior to sexual intercourse. To assess therapeutic efficacy, participants were required to record the mean intravaginal latency time for ejaculation (IELT). During the period of spray treatment, the nano-formulation of A. oleracea increased participant IELT values ( M = 293 s) compared with the baseline values (193 s). This nano-formulation reported clinical action in patients with premature ejaculation. It is accordingly considered to have potential application as a therapeutic alternative with benefits for both patients and their partners. Given the small number of participants in this study, further multicenter studies involving a larger number of participants are needed to confirm these observations.<\/jats:p>","DOI":"10.1177\/15579883231167819","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:57:32Z","timestamp":1682038652000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Safety of a Pharmaceutical Formulation Containing an Extract of\n                    <i>Acmella oleracea<\/i>\n                    (L.) in Patients With Premature Ejaculation: A Pilot Study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8075-4114","authenticated-orcid":false,"given":"Lecildo Lira","family":"Batista","sequence":"first","affiliation":[{"name":"Pharmaceutical Innovation Program, Department of Biological and Health Sciences, Universidade Federal do Amap\u00e1, Macap\u00e1, Brazil"},{"name":"Research Laboratory of Drugs, Department of Biological and Health Sciences, Universidade Federal do Amap\u00e1, Macap\u00e1, Brazil"},{"name":"Division of Urology, University Hospital, Federal University of Amap\u00e1, Macap\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary de Carvalho Rocha","family":"Koga","sequence":"additional","affiliation":[{"name":"Research Laboratory of Drugs, Department of Biological and Health Sciences, Universidade Federal do Amap\u00e1, Macap\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abrah\u00e3o Victor Tavares de Lima","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Research Laboratory of Drugs, Department of Biological and Health Sciences, Universidade Federal do Amap\u00e1, Macap\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6598-2442","authenticated-orcid":false,"given":"Thiago Afonso","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Division of Urology, University Hospital, Federal University of Amap\u00e1, Macap\u00e1, Brazil"},{"name":"Men\u2019s Health Study Group, Institute for Advanced Studies, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Postgraduate Program in Tropical Biodiversity, Federal University of Amap\u00e1, Macap\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester Lopes","family":"de Melo","sequence":"additional","affiliation":[{"name":"Research Laboratory of Drugs, Department of Biological and Health Sciences, Universidade Federal do Amap\u00e1, Macap\u00e1, Brazil"},{"name":"Postgraduate Program in Tropical Biodiversity, Federal University of Amap\u00e1, Macap\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos Tavares","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Pharmaceutical Innovation Program, Department of Biological and Health Sciences, Universidade Federal do Amap\u00e1, Macap\u00e1, Brazil"},{"name":"Research Laboratory of Drugs, Department of Biological and Health Sciences, Universidade Federal do Amap\u00e1, Macap\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"bibr1-15579883231167819","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009520"},{"key":"bibr2-15579883231167819","doi-asserted-by":"publisher","DOI":"10.1111\/and.13558"},{"issue":"3","key":"bibr3-15579883231167819","first-page":"61","volume":"28","author":"Andrade L. 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