{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:23:45Z","timestamp":1792225425208,"version":"4.4.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>The objective of the present study was to find out the association of folate genes MTR A2756G and MTRR A66G polymorphisms with the risk of male infertility. The databases of Google Scholar, PubMed, and Science Direct were searched to find relevant studies. Data were extracted from the eligible studies and were analyzed for pooled up odds ratio (OR) with 95% confidence interval (CI). Review Manager 5.4 was used for statistical analysis. Nineteen case-control studies were included in this meta-analysis which comprised 3621 cases and 3327 controls. Pooled analysis revealed that there is a significant association between MTR A2756G polymorphism with male infertility except for the dominant model. The ORs and 95% CI for each genetic model were as follows: 1.21 [1.03\u20131.42] for the allele model (G vs. A), 2.31 [1.38\u20133.96] for the additive model (GG vs. AA), 1.17 [0.98\u20131.38] for the dominant model (GG+AG vs. AA) and 2.10 [1.55\u20132.86] for the recessive model (GG vs. AG+AA). MTRR A66G has no noticeable association with male infertility. The current meta-analysis suggests that MTR A2756G polymorphism might be a potential risk factor for male infertility. In the future, the sample size should be increased to confirm the present results.<\/jats:p>","DOI":"10.1177\/15579883231176657","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T06:08:31Z","timestamp":1685426911000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of\n                    <i>MTR<\/i>\n                    A2756G and\n                    <i>MTRR<\/i>\n                    A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis"],"prefix":"10.1177","volume":"17","author":[{"given":"Tamjeed","family":"Tariq","sequence":"first","affiliation":[{"name":"Department of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Bibi","sequence":"additional","affiliation":[{"name":"Department of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaista","family":"Aslam","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Ishaq","sequence":"additional","affiliation":[{"name":"Department of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-2359","authenticated-orcid":false,"given":"Muhammad","family":"Irfan","sequence":"additional","affiliation":[{"name":"Department of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"bibr1-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2017.0062"},{"issue":"4","key":"bibr2-15579883231176657","first-page":"404","volume":"20","author":"Balkan M.","year":"2013","journal-title":"International Medical Journal"},{"key":"bibr3-15579883231176657","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.5.1445"},{"key":"bibr4-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.6"},{"key":"bibr5-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2022.102439"},{"issue":"4","key":"bibr6-15579883231176657","first-page":"17","volume":"17","author":"Farcas M. F.","year":"2009","journal-title":"Revista Rom\u00e2n\u0103 de Medicin\u0103 de Laborator"},{"key":"bibr7-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111411729"},{"key":"bibr8-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3002"},{"key":"bibr9-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20715"},{"key":"bibr10-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/70.3.659"},{"key":"bibr11-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.02.012"},{"key":"bibr12-15579883231176657","unstructured":"Kim S. Y., Lim J. W., Kim J. W., Park S. Y., Seo J. T. (2015). Association between genetic polymorphisms in folate-related enzyme genes and infertile men with non-obstructive azoospermia. Systems Biology in Reproductive Medicine, 61(5), 286\u2013292. https:\/\/doi.org\/10.3109\/19396368.2015.1049752"},{"key":"bibr13-15579883231176657","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2020.95418"},{"key":"bibr14-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-475738120140179"},{"key":"bibr15-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.12.1867"},{"key":"bibr16-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00431-X"},{"key":"bibr17-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del280"},{"key":"bibr18-15579883231176657","doi-asserted-by":"publisher","DOI":"10.4238\/2015.April.15.13"},{"key":"bibr19-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1038\/srep15548"},{"key":"bibr20-15579883231176657","unstructured":"Liu L., Cai Z., Leng H., Qian W. (2012). Association of MTHFR C677T and MS A2756G polymorphism with semen quality. Journal of Central South University (Medical Science), 37(10), 1054\u20131059. https:\/\/doi.org\/10.3969\/j.issn.1672-7347.2012.10.015"},{"key":"bibr21-15579883231176657","unstructured":"Ma F. M., Hou-Zhao W. (2017). Association of MTRR A66G polymorphism with male infertile. Chinese Journal of Birth Health Andheredity, 25(6), 120\u2013121."},{"key":"bibr22-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.12.001"},{"key":"bibr23-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.96"},{"key":"bibr24-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.10.028"},{"key":"bibr25-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0423-9"},{"key":"bibr26-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006540"},{"key":"bibr27-15579883231176657","unstructured":"Raigani M., Lakpour N., Soleimani M., Johari B., Sadeghi M. R. (2021). Association of\n                      MTHFR\n                      C677T and MTRR A66G gene polymorphisms with Iranian male infertility and its effect on seminal folate and vitamin B12. International Journal of Fertility & Sterility, 15(1), 20\u201325. https:\/\/doi.org\/10.22074\/ijfs.2021.6155"},{"key":"bibr28-15579883231176657","unstructured":"Ren S.Q., Mao Y., Nie Y., Yang W.Z., Li A., Lv Q., Wang D. (2019). Methionine synthase reductase A66G polymorphism and risk of male infertility: A meta-analysis. International Journal of Clinical and Experimental Medicine, 12(2), 1412\u20131419. www.ijcem.com"},{"key":"bibr29-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169789"},{"key":"bibr30-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018273"},{"issue":"1","key":"bibr31-15579883231176657","first-page":"89","volume":"12","author":"Sadiq M. F.","year":"2019","journal-title":"Jordan Journal of Biological Sciences"},{"key":"bibr32-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2021.2022723"},{"key":"bibr33-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112459232"},{"key":"bibr34-15579883231176657","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2018.00423"},{"key":"bibr35-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60531-7"},{"key":"bibr36-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.09.014"},{"key":"bibr37-15579883231176657","volume-title":"Association study of the level of folic acid in seminal plasma and single nucleotide polymorphisms in the genes of folate metabolism and idiopathic male infertility","author":"Wen-Bo Z.","year":"2010"},{"key":"bibr38-15579883231176657","volume-title":"Association study of single nucleotide polymorphisms in the genes of folate metabolism and idiopathic male infertility","author":"Xian-Jun Z.","year":"2007"},{"key":"bibr39-15579883231176657","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70223-7"}],"container-title":["American Journal of Men's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15579883231176657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15579883231176657","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15579883231176657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:27:28Z","timestamp":1777505248000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15579883231176657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/15579883231176657"],"URL":"https:\/\/doi.org\/10.1177\/15579883231176657","relation":{},"ISSN":["1557-9883","1557-9891"],"issn-type":[{"value":"1557-9883","type":"print"},{"value":"1557-9891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"article-number":"15579883231176657"}}