{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:40:34Z","timestamp":1780393234183,"version":"3.54.1"},"reference-count":87,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Human \u03b2-defensins (hBDs) are cationic peptides with an amphipathic spatial shape and a high cysteine content. The members of this peptide family have been found in the human body with various functions, including the human reproductive system. Of among \u03b2-defensins in the human body, \u03b2-defensin 1, \u03b2-defensin 2, and \u03b2-defensin 126 are known in the human reproductive system. Human \u03b2-defensin 1 interacts with chemokine receptor 6 (CCR6) in the male reproductive system to prevent bacterial infections. This peptide has a positive function in antitumor immunity by recruiting dendritic cells and memory T cells in prostate cancer. It is necessary for fertilization via facilitating capacitation and acrosome reaction in the female reproductive system. Human \u03b2-defensin 2 is another peptide with antibacterial action which can minimize infection in different parts of the female reproductive system such as the vagina by interacting with CCR6. Human \u03b2-defensin 2 could play a role in preventing cervical cancer via interactions with dendritic cells. Human \u03b2-defensin 126 is required for sperm motility and protecting the sperm against immune system factors. This study attempted to review the updated knowledge about the roles of \u03b2-defensin 1, \u03b2-defensin 2, and \u03b2-defensin 126 in both the male and female reproductive systems.<\/jats:p>","DOI":"10.1177\/15579883231182673","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T01:42:11Z","timestamp":1688002931000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Roles of Different \u03b2-Defensins in the Human Reproductive System: A Review Study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3743-4449","authenticated-orcid":false,"given":"Farzaneh","family":"Fesahat","sequence":"first","affiliation":[{"name":"Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1189-9037","authenticated-orcid":false,"given":"Amir Masoud","family":"Firouzabadi","sequence":"additional","affiliation":[{"name":"Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Zare-Zardini","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Imani","sequence":"additional","affiliation":[{"name":"Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"bibr1-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019404"},{"key":"bibr2-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-26797-5_19"},{"key":"bibr3-15579883231182673","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v31i1.335"},{"key":"bibr4-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioz171"},{"key":"bibr5-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1038\/77783"},{"key":"bibr6-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2410"},{"key":"bibr7-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60346-X"},{"key":"bibr8-15579883231182673","doi-asserted-by":"publisher","DOI":"10.2174\/1389203054065428"},{"key":"bibr9-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0317"},{"key":"bibr10-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00687-5"},{"key":"bibr11-15579883231182673","volume":"13","author":"Berscheid A.","year":"2017","journal-title":"PLOS Pathogens"},{"key":"bibr12-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12325"},{"key":"bibr13-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.05.012"},{"key":"bibr14-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.11.004"},{"key":"bibr15-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/1.1.51"},{"key":"bibr16-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24418"},{"issue":"12","key":"bibr17-15579883231182673","first-page":"1059","volume":"17","author":"Cao X. W.","year":"2011","journal-title":"Zhonghua Nan Ke Xue\/National Journal of Andrology"},{"key":"bibr18-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-3-75"},{"key":"bibr19-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.005389"},{"key":"bibr20-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.1756"},{"key":"bibr21-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-007-9197-7"},{"key":"bibr22-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-005-0936-5"},{"key":"bibr23-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.9.3952"},{"key":"bibr24-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009071"},{"key":"bibr25-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000063929.61760.F6"},{"key":"bibr26-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000057205.64451.B7"},{"key":"bibr27-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12502"},{"issue":"4","key":"bibr28-15579883231182673","first-page":"535","volume":"46","author":"Eccles M. R.","year":"2002","journal-title":"The International Journal of Developmental Biology"},{"key":"bibr29-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-118"},{"key":"bibr30-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.05.020"},{"key":"bibr31-15579883231182673","unstructured":"Firouzabadi A. M., Rezvani M. E., Zare F., Azizian H., Fesahat F. (n.d.). Possible impact of Human \u03b2-defensin 1 on sperm motility in subfertile men with abnormal sperm parameters. [Unpublished manuscript]"},{"key":"bibr32-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1038\/nri1180"},{"key":"bibr33-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1080\/02713680590968637"},{"key":"bibr34-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1038\/43088"},{"key":"bibr35-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.5074"},{"key":"bibr36-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1530\/REP-07-0564"},{"key":"bibr37-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00107-9"},{"key":"bibr38-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7646com"},{"key":"bibr39-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38498-7"},{"key":"bibr40-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1111\/and.13455"},{"key":"bibr41-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.06.002"},{"key":"bibr42-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.01.006"},{"key":"bibr43-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4781"},{"key":"bibr44-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.12.082"},{"key":"bibr45-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09090.x"},{"key":"bibr46-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-4-12"},{"key":"bibr47-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro976"},{"key":"bibr48-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.346098"},{"key":"bibr49-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02804-12"},{"key":"bibr50-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4038"},{"key":"bibr51-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02675.x"},{"key":"bibr52-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.3730-3739.2003"},{"key":"bibr53-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.suppl_2.ii17"},{"key":"bibr54-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5540-2"},{"key":"bibr55-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.016"},{"key":"bibr56-15579883231182673","doi-asserted-by":"publisher","DOI":"10.22435\/jbmi.v9i2.4417"},{"key":"bibr57-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27828"},{"key":"bibr58-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/606459"},{"key":"bibr59-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)84952-9"},{"key":"bibr60-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1038\/ni1206"},{"key":"bibr61-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53298-1"},{"key":"bibr62-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1159\/000336619"},{"key":"bibr63-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1530\/REP-14-0163"},{"key":"bibr64-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340200107"},{"key":"bibr65-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioac197"},{"key":"bibr66-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2894722"},{"key":"bibr67-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1080\/14767050601036212"},{"key":"bibr68-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/0959-440X(95)80015-S"},{"key":"bibr69-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.498"},{"key":"bibr70-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22859"},{"key":"bibr71-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20286"},{"key":"bibr72-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.109"},{"key":"bibr73-15579883231182673","volume":"3","author":"Tollner T. L.","year":"2014","journal-title":"Science Translational Medicine"},{"key":"bibr74-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den276"},{"key":"bibr75-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.11.002"},{"key":"bibr76-15579883231182673","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2516"},{"key":"bibr77-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02246-9"},{"key":"bibr78-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.1.9"},{"key":"bibr79-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.525"},{"key":"bibr80-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.042432"},{"key":"bibr81-15579883231182673","doi-asserted-by":"publisher","DOI":"10.21608\/bfsa.2021.174150"},{"key":"bibr82-15579883231182673","doi-asserted-by":"publisher","DOI":"10.3109\/13625187.2015.1052395"},{"key":"bibr83-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1515\/tjb-2016-0269"},{"key":"bibr84-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1038\/415389a"},{"key":"bibr85-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)01123-4"},{"key":"bibr86-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1021\/bi00041a048"},{"key":"bibr87-15579883231182673","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01409-w"}],"container-title":["American Journal of Men's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15579883231182673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15579883231182673","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15579883231182673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:27:30Z","timestamp":1777505250000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15579883231182673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":87,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/15579883231182673"],"URL":"https:\/\/doi.org\/10.1177\/15579883231182673","relation":{},"ISSN":["1557-9883","1557-9891"],"issn-type":[{"value":"1557-9883","type":"print"},{"value":"1557-9891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"article-number":"15579883231182673"}}