{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:49:46Z","timestamp":1792702186811,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Varicocele surgical repair can improve the function of the testis for patients with varicocele. We carried out a systematic review and meta-analysis to assess the effects of varicocele surgical repair on serum hormones and inhibin B levels in patients with varicocele. A literature search was performed in August 2022, and no language or geographic region restrictions were applied. The search included the following databases: PubMed, Embase, and Medline. A literature review was performed to identify all published clinical trials assessing serum hormone and inhibin B levels before and after varicocele surgical repair. The reference lists of retrieved studies were also investigated. A systematic review and meta-analysis were conducted. Eight articles were selected from 162 articles, including 452 patients. The combined analysis showed that after surgical treatment, mean serum testosterone, inhibin B, and sperm concentration levels increased compared with preoperative levels ( p &lt; .05). After surgical treatment, mean serum follicle-stimulating hormon (FSH), and Luteinizing hormone (LH) levels decreased compared with preoperative levels ( p &lt; .05). This meta-analysis demonstrates that varicocele surgical repair can improve testicular function, increase serum testosterone, and inhibin B levels and decrease serum FSH and LH levels in patients with varicocele. This might be related to the improvement of infertility. A large-scale multicenter randomized controlled study is needed for further confirmation.<\/jats:p>","DOI":"10.1177\/15579883231199400","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:19:29Z","timestamp":1694416769000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Varicocele Surgical Repair on Serum Hormone and Inhibin B Levels for Patients With Varicocele: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"17","author":[{"given":"Daxue","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Urology, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, Tengzhou Central People\u2019s Hospital, Tengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-0590","authenticated-orcid":false,"given":"Diandong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaisheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"bibr1-15579883231199400","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.172640"},{"key":"bibr2-15579883231199400","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-015-1320-8"},{"key":"bibr3-15579883231199400","doi-asserted-by":"publisher","DOI":"10.1159\/000322825"},{"key":"bibr4-15579883231199400","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2016.34.2.101"},{"key":"bibr5-15579883231199400","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1411-70"},{"key":"bibr6-15579883231199400","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2007.00747.x"},{"key":"bibr7-15579883231199400","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.9.1945"},{"key":"bibr8-15579883231199400","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.48"},{"key":"bibr9-15579883231199400","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38874-2"},{"key":"bibr10-15579883231199400","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2016.01.009"},{"key":"bibr11-15579883231199400","unstructured":"Higgins J. 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