{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:47:32Z","timestamp":1777855652084,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>We report a case of a very rare association of adrenal adenoma, unilateral adrenal hyperplasia, and bilateral renal artery stenosis. A 61-year-old man with a remarkable history of two severe strokes was admitted to the Nephrology department with hypertension associated with severe hypokalemia and metabolic alkalosis. Doppler of renal arteries was not conclusive, so contrast-enhanced scanning was done revealing a left adrenal adenoma, right adrenal hyperplasia, and bilateral moderate renal artery stenosis. After control of blood pressure with central anti-hypertensive drugs and calcium channel blockers and normalization of kalemia under potassium supplementation, the hormonal analysis was done showing an elevated plasma aldosterone concentration at 1,568 pmol\/L, with a direct renin concentration below the detection level. Primary aldosteronism was confirmed and the prescription of an anti-aldosterone agent led to the control of blood pressure and potassium plasmatic levels. In front of arterial hypertension with hypokalemia, we recommend the assessment of secondary and primary hyperaldosteronism in a systematic way since the association of two or even three etiologies of hyperaldosteronism is possible and an appropriate diagnosis is essential for adequate treatment.<\/jats:p>","DOI":"10.1177\/15579883241309769","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T07:11:26Z","timestamp":1735024286000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent Adrenal Adenoma, Unilateral Adrenal Hyperplasia, and Bilateral Renal Artery Stenosis in a 61-Year-Old Man"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-5422","authenticated-orcid":false,"given":"Sanda","family":"Mrabet","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation, Facult\u00e9 de M\u00e9decine de Sousse, Universit\u00e9 de Sousse, H\u00f4pital Sahloul, Sousse, Tunisie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-9938","authenticated-orcid":false,"given":"Achraf","family":"Jaziri","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation, Facult\u00e9 de M\u00e9decine de Sousse, Universit\u00e9 de Sousse, H\u00f4pital Sahloul, Sousse, Tunisie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorsaf","family":"Zellama","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation, Facult\u00e9 de M\u00e9decine de Sousse, Universit\u00e9 de Sousse, H\u00f4pital Sahloul, Sousse, Tunisie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdellatif","family":"Achour","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation, Facult\u00e9 de M\u00e9decine de Sousse, Universit\u00e9 de Sousse, H\u00f4pital Sahloul, Sousse, Tunisie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosra","family":"Hasni","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology, Facult\u00e9 de M\u00e9decine de Sousse, Universit\u00e9 de Sousse, H\u00f4pital Sahloul, Sousse, Tunisie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza","family":"Elfekih","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology, Facult\u00e9 de M\u00e9decine de Sousse, Universit\u00e9 de Sousse, H\u00f4pital Sahloul, Sousse, Tunisie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtissem Hasni","family":"Bouraoui","sequence":"additional","affiliation":[{"name":"Department of Radiology, Facult\u00e9 de M\u00e9decine de Sousse, Universit\u00e9 de Sousse, H\u00f4pital Farhat Hached, Sousse, Tunisie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Amine","family":"Chaari","sequence":"additional","affiliation":[{"name":"Department of Radiology, Facult\u00e9 de M\u00e9decine de Sousse, Universit\u00e9 de Sousse, H\u00f4pital Farhat Hached, Sousse, Tunisie"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"bibr1-15579883241309769","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.12.2735"},{"key":"bibr2-15579883241309769","unstructured":"Dominguez A., Muppidi V., Gupta S. (2022). Hyperaldosteronism. In Statpearls. Statpearls. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499983\/"},{"key":"bibr3-15579883241309769","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4061"},{"key":"bibr4-15579883241309769","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2019.08.007"},{"key":"bibr5-15579883241309769","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2020.1790586"},{"key":"bibr6-15579883241309769","unstructured":"Papadopoulou-Marketou N., Vaidya A., Dluhy R., Chrousos G. P. (2000). Hyperaldosteronism. In Feingold K. R., Anawalt B., Boyce A., Chrousos G., de Herder W. W., Dhatariya K., Dungan K., Hershman J. M., Hofland J., Kalra S., Kaltsas G., Koch C., Kopp P., Korbonits M., Kovacs C. S., Kuohung W., Laferr\u00e8re B., Levy M., McGee E. A., Wilson D. P. (Eds.). Endotext. 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