{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:40:59Z","timestamp":1792129259947,"version":"4.4.0"},"reference-count":63,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Sichuan Province","award":["2024NSFSC1676"],"award-info":[{"award-number":["2024NSFSC1676"]}]},{"name":"Special Support for Postdoctoral Research Project of Sichuan Province in 2024","award":["No. TB2024077"],"award-info":[{"award-number":["No. TB2024077"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    Varicocele can lead to impaired semen parameters and induce infertility. Varicocelectomy is considered the gold standard for varicocele treatment. However, its impact on improving assisted reproductive technologies (ARTs) outcomes remains contentious. This study seeks to compare reproductive outcomes between infertile men who underwent varicocelectomy and those who did not prior to ARTs. In addition, it evaluates the influence of types of fertilization, couples\u2019 ages, and treatment years on clinical pregnancy rates. A comprehensive search was conducted through February 2023 across eight electronic databases using combinations of relevant keywords. Observational and randomized controlled trials (RCTs) were included. Fourteen eligible studies (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20091,705) were included: 12 retrospective studies (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20091,467) and 2 prospective studies (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009238). Pooled results indicated that infertile men who received varicocelectomy had a significantly higher clinical pregnancy rate compared to the control group (OR: 1.38, 95% CI [1.05, 1.83];\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200936%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.02). The live birth rate was also significantly higher in the treatment group (OR: 2.18, [1.58, 3.01];\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.00001;\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090%). However, miscarriage rates did not significantly differ (OR: 1.07; [0.57, 1.98];\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.84). Varicocelectomy significantly improved sperm concentration and normal morphology rate, but did not result in a significant enhancement in sperm motility. Men who underwent varicocelectomy between 2012 and 2019 and subsequently received intracytoplasmic sperm injection exhibited improved outcomes, particularly when their female partners were under 30\u2009years of age. Larger, high-quality RCTs are needed to clarify benefits or avoid unnecessary treatments.\n                  <\/jats:p>","DOI":"10.1177\/15579883251334561","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T07:42:13Z","timestamp":1745826133000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Influence of Varicocelectomy on Assisted Reproductive Technology Outcomes of Infertile Patients with Varicocele: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"19","author":[{"given":"Wending","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Reproductive Health and Infertility, Chengdu Women\u2019s and Children\u2019s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Jinxin Xinan Women\u2019s and Children\u2019s Hospital, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-539X","authenticated-orcid":false,"given":"Penghao","family":"Li","sequence":"additional","affiliation":[{"name":"Jinxin Xinan Women\u2019s and Children\u2019s Hospital, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","unstructured":"Agarwal A. Sharma R. K. Sharma R. Assidi M. Abuzenadah A. M. Alshahrani S. Durairajanayagam D. Sabanegh E. (2014). Characterizing semen parameters and their association with reactive oxygen species in infertile men. Reproductive Biology and Endocrinology 12 33. https:\/\/doi.org\/10.1186\/1477-7827-12-33","DOI":"10.1186\/1477-7827-12-33"},{"key":"e_1_3_3_3_1","doi-asserted-by":"crossref","unstructured":"Al-Mohammady A. A. El-Sherbiny A. F. Mehaney A. B. Ghobara Y. A. (2019). Varicocele repair in patients prepared for intracytoplasmic sperm injection: To do or not to do? Andrologia 51(2) e13185. https:\/\/doi.org\/10.1111\/and.13185","DOI":"10.1111\/and.13185"},{"key":"e_1_3_3_4_1","doi-asserted-by":"crossref","unstructured":"Ameli M. Ahmadzadeh M. Khajavi A. Nabizadeh M. (2019). Evaluation of the success rate and complications of conventional varicocelectomy: Do we need microscopic surgery really? 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