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Lumbar disk herniation (LDH) may compress the dural sac and irritate the cauda equina, producing subclinical symptoms that overlap with those of CP\/CPPS and increasing the likelihood of misdiagnosis. We report the case of a 61-year-old man with an 8-year history of CP\/CPPS unresponsive to standard treatments, including phytotherapy, anti-inflammatory agents, and physical therapy. Further evaluation revealed lower-limb weakness and low-back pain; lumbar CT identified disk herniation with dural sac compression. Treatment was revised to include traditional Chinese medicine (Mai Xue Kang capsules and a modified Chaihu\u2014Guizhi\u2014Ganjiang Decoction) along with lifestyle modifications, resulting in significant symptom relief and no recurrence at 6-week follow-up. A review of the literature supports the potential for LDH to mimic CP\/CPPS symptoms, highlighting a diagnostic blind spot. This case emphasizes the importance of considering spinal etiologies in refractory CP\/CPPS and advocates for a broadened diagnostic framework to enable more personalized treatment strategies.<\/jats:p>","DOI":"10.1177\/15579883251377300","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:36:17Z","timestamp":1758198977000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Lumbar Disk Herniation a Potential Risk Factor for Chronic Prostatitis\/Chronic Pelvic Pain Syndrome? Insights From a Misdiagnosed Case"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-1071","authenticated-orcid":false,"given":"Dawei","family":"Gao","sequence":"first","affiliation":[{"name":"Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Qinghai University Medical College, Xining, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuyu","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China"},{"name":"Department of the Core Facility, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Jin","sequence":"additional","affiliation":[{"name":"Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China"},{"name":"Reproductive Medicine Center, Zhongda Hospital, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijia","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Medicine, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Qinghai University Medical College, Xining, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyi","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Medicine, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baofang","family":"Jin","sequence":"additional","affiliation":[{"name":"Andrology Department of Integrative Medicine, Zhongda Hospital, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalin","family":"Sun","sequence":"additional","affiliation":[{"name":"Andrology Department of Integrative Medicine, Zhongda Hospital, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"crossref","unstructured":"Ajimsha M. 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