{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:48:08Z","timestamp":1777855688626,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    This study compared the efficacies of single-dose ceftriaxone therapy at doses of 250 mg, 500 mg, and 1 g for gonococcal paraurethral duct infection in men. Forty-eight men with gonococcal paraurethral duct infection were assigned to Groups A, B, and C based on their order of arrival in the clinic; each group comprised 16 patients. Groups A, B, and C received single intramuscular doses of ceftriaxone at 250 mg, 500 mg, and 1 g, respectively. The mean times to resolution of purulent discharge from the paraurethral duct were 1.87 \u00b1 0.81 days in Group A, 1.06 \u00b1 0.25 days in Group B, and 1.13 \u00b1 0.34 days in Group C. The mean times to resolution of erythematous swelling at skin lesions were 4.75 \u00b1 1.69 days in Group A, 3.44 \u00b1 0.89 days in Group B, and 3.31 \u00b1 1.25 days in Group C. The mean times to resolution of tenderness at skin lesions were 5.25 \u00b1 1.00 days in Group A, 3.06 \u00b1 0.10 days in Group B, and 2.38 \u00b1 1.03 days in Group C. The mean times to closure of the paraurethral duct orifice were 9.88 \u00b1 2.92 days in Group A, 6.88 \u00b1 1.71 days in Group B, and 6.38 \u00b1 1.86 days in Group C. The resolution times significantly differed between Group A and Groups B and C (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; .05); however, there were no significant differences between Groups B and C (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &gt; .05). The study shows that all three ceftriaxone single-dose regimens effectively cured gonococcal paraurethral duct infection in men. A single 500 mg dose may represent a more suitable treatment option.\n                  <\/jats:p>","DOI":"10.1177\/15579883251412987","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:23:20Z","timestamp":1768976600000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacies of Single-Dose Ceftriaxone Regimens in Treating Gonococcal Paraurethral Duct Infection in Men"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5597-4417","authenticated-orcid":false,"given":"Wenge","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Dermatology, First People\u2019s Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Nantong University Affiliated Qidong Hospital, Qidong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, First People\u2019s Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, First People\u2019s Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2011.011267"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009485"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2010.519377"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1557988318772753"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2014-051773"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1557988319849134"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166355"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/15579883231152111"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12638"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484697"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2011.011319"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462419886775"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(84)90217-6"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000819"},{"key":"e_1_3_3_16_1","first-page":"137","article-title":"The pathology of gonorrhoea","volume":"24","author":"Harkness A. H.","year":"1948","unstructured":"Harkness A. H. (1948). The pathology of gonorrhoea. The British Journal of Venereal Diseases, 24, 137\u2013147.","journal-title":"The British Journal of Venereal Diseases"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw180"},{"key":"e_1_3_3_18_1","first-page":"144","author":"King A.","year":"1969","unstructured":"King A., Nicol C. (1969). Venereal diseases (2nd ed., pp. 144\u2013161). F. A. Davis Company.","journal-title":"Venereal diseases"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555567154159"},{"key":"e_1_3_3_20_1","first-page":"14622","article-title":"Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from symptomatic men attending the Nanjing sexually transmitted diseases clinic (2011-2012): Genetic characteristics of isolates with reduced sensitivity to ceftriaxone","volume":"27","author":"Li S.","year":"2014","unstructured":"Li S., Su X. H., Le W. J., Jiang F. X., Wang B. X., Peter A. R. (2014). Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from symptomatic men attending the Nanjing sexually transmitted diseases clinic (2011-2012): Genetic characteristics of isolates with reduced sensitivity to ceftriaxone. BMC Infectious Diseases, 27, 14622.","journal-title":"BMC Infectious Diseases"},{"key":"e_1_3_3_21_1","first-page":"69","volume-title":"Chemotherapeutic properties of antibiotics: Protein binding antibiotics\u2014An introduction","author":"Reiner R.","year":"1982","unstructured":"Reiner R. (1982). Chemotherapeutic properties of antibiotics: Protein binding antibiotics\u2014An introduction (p. 69). 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