{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:40:48Z","timestamp":1792305648151,"version":"4.4.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Hyaluronan-binding protein 1 (HABP1), alternatively designated as p32, C1QBP, gC1qR, or HIV TAP (Tat-associated protein), is a highly conserved eukaryotic protein expressed across taxa from yeast to mammals, and is localized on the cell surface of diverse cell types. This protein exists in two distinct functional forms: firstly, a pro-protein exclusively found in male germ cells, suggesting its crucial role in spermatogenic differentiation; and secondly, a mature, post-translationally cleaved form localized on the sperm surface. Due to its specific affinity for hyaluronan (HA) a key constituent of reproductive fluids the mature form is actively involved in sperm penetration, sperm-oocyte interaction, and subsequent fertilization by mature human spermatozoa. This review aims to comprehensively elucidate the key functions of HABP1, with a specific focus on its implications in reproductive science.<\/jats:p>","DOI":"10.1177\/15579883261499125","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:54:22Z","timestamp":1792068862000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyaluronan-Binding Protein 1 (HBAP-1) in Male Reproduction"],"prefix":"10.1177","volume":"20","author":[{"given":"Mahdi","family":"Dehghan-Manshadi","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3743-4449","authenticated-orcid":false,"given":"Farzaneh","family":"Fesahat","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5731-4612","authenticated-orcid":false,"given":"Hossein","family":"Ansariniya","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences"},{"name":"Shahid Sadoughi University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.10135"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh835"},{"issue":"8","key":"e_1_3_4_4_1","first-page":"495","article-title":"Sperm parameters, protamine deficiency, and apoptosis in total globozoospermia","volume":"13","author":"Ghasemzadeh J.","year":"2015","unstructured":"Ghasemzadeh J., Talebi A. R., Khalili M. A., Fesahat F., Halvaei I., Nabi A., Ashourzadeh S. (2015). Sperm parameters, protamine deficiency, and apoptosis in total globozoospermia. 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