{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:34:44Z","timestamp":1792906484374,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Medical and Health Science Program of Zhejiang Province","award":["2025KY1665"],"award-info":[{"award-number":["2025KY1665"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paclitaxel (PTX) is an effective chemotherapeutic agent for prostate cancer (PCa), yet resistance emerges with disease progression. Cancer-cell stemness is intimately linked to PTX resistance. This work clarifies whether FOXG1 modulates PTX resistance in PCa via cellular stemness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TCGA database was interrogated for FOXG1 expression in PCa. PTX-resistant PCa cell lines were generated by stepwise escalation of PTX concentration. qRT-PCR quantified FOXG1 and NANOG levels in PCa cells. CCK-8, sphere-formation assay, and flow cytometry evaluated cell viability, stemness, and apoptosis, respectively. Western blot assessed apoptosis-related proteins. JASPAR predicted FOXG1 binding sites within NANOG. Dual-luciferase reporter and ChIP verified FOXG1\u2013NANOG interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bioinformatic analysis revealed elevated FOXG1 expression in PCa tissues. FOXG1 levels were likewise increased in PCa cells. A PTX-resistant PC-3 sub-line (PC-3-R) was established. FOXG1 silencing suppressed stemness and viability of PC-3-R cells under PTX exposure while promoting apoptosis. FOXG1 was identified as an upstream regulator of NANOG. NANOG overexpression reversed the effects conferred by FOXG1 silencing on PC-3-R cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FOXG1 fosters NANOG-mediated cellular stemness to potentiate PTX resistance in PCa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15579883261500924","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:47:31Z","timestamp":1792694851000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["FOXG1 Enhances Paclitaxel Resistance in Prostate Cancer via NANOG-Mediated Cellular Stemness"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4103-7110","authenticated-orcid":false,"given":"Chong","family":"Shen","sequence":"first","affiliation":[{"name":"Shaoxing People\u2019s Hospital"},{"name":", The First Hospital of Shaoxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ren","sequence":"additional","affiliation":[{"name":"Shaoxing People\u2019s Hospital"},{"name":", The First Hospital of Shaoxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2536-6699","authenticated-orcid":false,"given":"Xiangrong","family":"Ying","sequence":"additional","affiliation":[{"name":"Shaoxing People\u2019s Hospital"},{"name":", The First Hospital of Shaoxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Shaoxing People\u2019s Hospital"},{"name":", The First Hospital of Shaoxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanchuan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Shaoxing People\u2019s Hospital"},{"name":", The First Hospital of Shaoxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengang","family":"Luo","sequence":"additional","affiliation":[{"name":"Shaoxing People\u2019s Hospital"},{"name":", The First Hospital of Shaoxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuixiang","family":"Tao","sequence":"additional","affiliation":[{"name":"Shaoxing People\u2019s Hospital"},{"name":", The First Hospital of Shaoxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shaoxing People\u2019s Hospital"},{"name":", The First Hospital of Shaoxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2024.102818"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-025-01104-9"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271221129854"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-023-00981-9"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e19540"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.11.001"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2021-0228"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2023.06.009"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06451-w"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17101356"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/140590"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2024.2393442"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13258-021-01074-3"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.04.004"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja2021117"},{"key":"e_1_3_6_17_1","first-page":"111875","article-title":"Saikosaponin-d mediates FOXG1 to reverse docetaxel resistance in prostate cancer through oxidative phosphorylation","volume":"829","author":"Meng J.","year":"2024","unstructured":"Meng J., Yang B., Shu C., Jiang S. 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