{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:57:27Z","timestamp":1790315847211,"version":"4.1.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hand (New York, N,Y.)"],"published-print":{"date-parts":[[2017,9]]},"abstract":"\n Background:<\/jats:bold>\n Collagenase\n Clostridium histolyticum<\/jats:italic>\n (CCH) injection and manipulation is a relatively new method for treating Dupuytren contracture that is growing in popularity. Although side effects such as swelling and ecchymosis are common, they are typically mild and self-limited. Major complications are rare but have included flexor tendon rupture and complex regional pain syndrome.\n Methods:<\/jats:bold>\n This study describes a case report of 2 patients seen at our institution.\n Results:<\/jats:bold>\n Here, we report 2 patients seen at our institution each with different, yet serious complications after CCH injection and manipulation. One patient had extensive skin loss and chose amputation over reconstruction. The other patient had loss of perfusion and required finger amputation.\n Conclusions:<\/jats:bold>\n Although it is unclear how directly the administration of CCH is connected to the observed complications, physicians should recognize the potential for serious rare complications in any treatment of Dupuytren contracture.\n <\/jats:p>","DOI":"10.1177\/1558944717711461","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T10:08:36Z","timestamp":1498039716000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Complications Following Collagenase Treatment for Dupuytren Contracture"],"prefix":"10.1177","volume":"12","author":[{"given":"Jennifer","family":"Wozniczka","sequence":"first","affiliation":[{"name":"Oregon Health & Science University, Portland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Canepa","sequence":"additional","affiliation":[{"name":"The Oregon Clinic, Portland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Mirarchi","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University, Portland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University, Portland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000152420.64842.B6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753193413490899."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2015.04.036."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-012-9407-3."},{"issue":"1","key":"e_1_3_2_6_2","first-page":"17","article-title":"Microvascular response to locally injected collagenase. An experimental investigation in hamsters and rabbits","volume":"23","author":"Rydevik B","year":"1989","unstructured":"Rydevik B, Ehira T, Linder L, Olmarker K, Romanus M, Branemark PI. Microvascular response to locally injected collagenase. An experimental investigation in hamsters and rabbits. Scand J Plast Reconstr Surg Hand Surg. 1989;23(1):17-21.","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753193413517075."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(96)80368-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000237039.71227.11."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008200109016842"},{"key":"e_1_3_2_11_2","unstructured":"United States FDA Report. Briefing document for collagenase Clostridium histolyticum (AA4500) in the treatment of advanced Dupuytren\u2019s disease. Arthritis Advisory Committee Meeting September 16 2009. https:\/\/www.fda.gov\/downloads\/AdvisoryCommittees\/committeesmeetingmaterials\/drugs\/arthritisadvisorycommittee\/ucm182015.pdf"}],"container-title":["HAND"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1558944717711461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1558944717711461","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1558944717711461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:28:42Z","timestamp":1777447722000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1558944717711461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,21]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1177\/1558944717711461"],"URL":"https:\/\/doi.org\/10.1177\/1558944717711461","relation":{},"ISSN":["1558-9447","1558-9455"],"issn-type":[{"value":"1558-9447","type":"print"},{"value":"1558-9455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,21]]}}}