{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:56:16Z","timestamp":1777661776361,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Endo Pharmaceuticals Inc."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hand (New York, N,Y.)"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Background: Dupuytren contracture (DC) treatment with collagenase clostridium histolyticum (CCH) has lower associated treatment costs than fasciectomy, but real-world, postprocedure return-to-function data are limited. Methods: This retrospective study used a US claims database and included adults treated for DC with CCH or fasciectomy (first treatment = index date), who had continuous health plan enrollment \u2265360 days preindex and \u226590 days postindex (ie, 90-day follow-up). Analgesic use and physical therapy (PT) and occupational therapy (OT) visits during the follow-up were used as surrogate markers for return-to-function. Results: Overall, 1654 and 2745 patients were included in the CCH and fasciectomy cohorts, respectively. A significantly lower percentage of patients in the CCH versus fasciectomy cohort used opioid analgesics (32.3% vs 82.7%; P &lt; .0001), used nonsteroidal anti-inflammatory drugs (8.6% vs 17.2%; P &lt; .0001), or had \u22651 DC-specific PT or OT visit during follow-up (PT, 38.9% vs 45.3% [ P &lt; .0001]; OT, 32.8% vs 38.0% [ P = .0006]). The mean number of DC-specific PT and OT visits (PT, 2.5 vs 6.4 [ P &lt; .0001]; OT, 1.4 vs 1.9 [ P &lt; .0001]) per patient was significantly lower in the CCH versus fasciectomy cohort. Conclusions: This analysis using surrogate markers suggests that CCH treatment may allow earlier return-to-function than fasciectomy in adults treated for DC.<\/jats:p>","DOI":"10.1177\/1558944720919923","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T08:47:16Z","timestamp":1591519636000},"page":"491-498","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Return-to-Function Following Treatment of Dupuytren Contracture With Collagenase Clostridium Histolyticum Versus Fasciectomy"],"prefix":"10.1177","volume":"17","author":[{"given":"Victoria M.","family":"Divino","sequence":"first","affiliation":[{"name":"IQVIA, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitch","family":"DeKoven","sequence":"additional","affiliation":[{"name":"IQVIA, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9946-7572","authenticated-orcid":false,"given":"David","family":"Hurley","sequence":"additional","affiliation":[{"name":"Endo Pharmaceuticals Inc., Malvern, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,7]]},"reference":[{"key":"bibr1-1558944720919923","doi-asserted-by":"publisher","DOI":"10.1177\/1558944716647101"},{"key":"bibr2-1558944720919923","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-010-9306-4"},{"key":"bibr3-1558944720919923","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.180"},{"key":"bibr4-1558944720919923","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2013.03.036"},{"key":"bibr5-1558944720919923","doi-asserted-by":"publisher","DOI":"10.1016\/j.jht.2008.08.003"},{"key":"bibr6-1558944720919923","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2012.670678"},{"key":"bibr7-1558944720919923","unstructured":"Xiaflex\u00ae (collagenase clostridium histolyticum) for injection, for intralesional use\n                      [Package insert]. 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