{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:25:30Z","timestamp":1783542330125,"version":"3.55.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100014535","name":"center for individualized medicine, mayo clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014535","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hand (New York, N,Y.)"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Controversy exists regarding the influence of breast cancer\u2013related lymphedema (BCRL) in the development of peripheral neuropathies. Our aim was to evaluate the association of secondary lymphedema with peripheral neuropathies in patients with breast cancer. We performed a systematic review by querying PubMed, EMBASE, Ovid Medline and Epub Ahead of Print, In-Process &amp; Other Non-Indexed Citations, and Cochrane Central Register of Controlled Trials databases. The keywords \u201clymphedema\u201d AND (\u201cneuropathy\u201d OR \u201ccarpal tunnel syndrome\u201d OR \u201ccubital tunnel syndrome\u201d OR \u201cneuropathic pain\u201d) and synonyms in titles and abstracts were used to perform the search. Seventeen articles met the inclusion criteria. Discrepancies were found in studies that analyzed whether a cause-effect association exists between carpal tunnel syndrome (CTS) and secondary lymphedema. No evidence indicated that lymphedema predisposes to developing peripheral neuropathies such as CTS or brachial plexopathy. No studies found an association between patients with breast cancer at risk of or with lymphedema and the development or worsening of CTS. Carpal tunnel release can be safely performed in patients with BCRL. Neuropathic pain worsens with lymphedema, and treatment seems to improve the pain. Our study did not find enough evidence to conclude that BCRL is associated with the development of peripheral neuropathies. Carpal tunnel release is a safe procedure that can be performed in patients with BCRL and does not influence the development or worsening of lymphedema. Neuropathic pain seems to worsen after development of lymphedema, and treatment has been found to improve neuropathic pain.<\/jats:p>","DOI":"10.1177\/1558944720963944","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T21:42:59Z","timestamp":1603143779000},"page":"668-675","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["A Systematic Review of Peripheral Neuropathies in Breast Cancer\u2013Related Lymphedema"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2004-7538","authenticated-orcid":false,"given":"Antonio J.","family":"Forte","sequence":"first","affiliation":[{"name":"Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Huayllani","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Jacksonville, FL, 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