{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:57:09Z","timestamp":1777661829509,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hand (New York, N,Y.)"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>This systematic review investigates complications and recurrence of Dupuytren\u2019s contracture in metacarpophalangeal joints (MCPJs) and\/or proximal interphalangeal joints (PIPJs) of fingers treated with collagenase clostridium histolyticum (CCH). A review of the literature on Dupuytren\u2019s disease was performed using PRISMA guidelines. Included publications described complications and\/or recurrences for contractures \u226520\u00b0 in MCPJs and\/or PIPJs treated with CCH. Successful treatments reduced contractures to \u22645\u00b0 immediately. Treatment-related adverse events (AEs) were classified as minor, major surgical, and major nonsurgical. Contracture recurrence involved return of fixed-flexion contracture \u226520\u00b0 in a successfully treated finger in patients with \u226512 months of follow-up. Of 2675 patients (3753 joints), 94% experienced \u22651 treatment-related AE, most commonly peripheral edema (64%), pain in extremity (53%), and contusion (51%). Major surgical complications occurred in 9 patients (1.0%). Major nonsurgical complications occurred in 2 patients, specifically nonrupture tendon injury and anaphylaxis. Of 1488 patients (2069 joints), recurrences were reported in 23% of successfully treated joints (n = 466; 20% MCPJs, 28% PIPJs), on average 12 to 24 months after treatment. MCPJs achieved greater success than PIPJs in initial contracture reduction (77% versus 36%). CCH is a safe, effective treatment to improve hand function in Dupuytren\u2019s contracture. Most AEs are minor and self-resolving, although the risk of major AEs still exists. Following treatment, 23% of successfully treated joints experience recurrence, typically within 12 to 24 months but sometimes as early as 6 months. Surgeons are encouraged to discuss these risks with patients for shared decision-making regarding optimal treatment modalities.<\/jats:p>","DOI":"10.1177\/1558944720974119","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T01:06:20Z","timestamp":1611277580000},"page":"815-824","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of Dupuytren\u2019s Contracture With Collagenase: A Systematic Review"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5784-9473","authenticated-orcid":false,"given":"Alexis B.","family":"Sandler","sequence":"first","affiliation":[{"name":"The George Washington University, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Scanaliato","sequence":"additional","affiliation":[{"name":"William Beaumont Army Medical Center, El Paso, TX, 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