{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T15:35:53Z","timestamp":1788104153661,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hand (New York, N,Y.)"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dupuytren disease is a common fibroproliferative disease that affects the palmar fascia of the hands. Currently, there is limited consensus regarding the optimal therapy for this condition, with treatment decisions based largely on surgeon preference. Therefore, the aim of this study was to determine which treatments are the most effective for Dupuytren disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>A systematic review and network meta-analyses were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Medline, EMBASE, and Web of Science were searched for randomized trials comparing treatments for Dupuytren disease in adults. Eligible treatments included open limited fasciectomy, collagenase injection, and percutaneous needle fasciotomy. Study selection, data extraction, and quality appraisal were performed in duplicate. The methodological quality was evaluated with the Cochrane risk-of-bias critical appraisal tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eleven randomized clinical trials were included in this study. At short-term (1-12 weeks) and long-term (2-5 years) time points, fasciectomy improved contracture release more than collagenase and needle fasciotomy as inferred by a lower total passive extension deficit. However, there was no difference between the groups regarding the best possible outcome at any time point. Fasciectomy was also superior in terms of recurrence and patient satisfaction compared with collagenase and needle fasciotomy, but only at later time points. There was no difference in skin damage\u2013related and nerve damage\u2013related complications following fasciectomy compared with other modalities. Risk of bias was generally moderate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Fasciectomy provides superior long-term advantages in terms of patient outcomes when compared with collagenase and needle fasciotomy. Larger trials with better blinding of outcome assessors are needed in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15589447231174175","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T02:02:55Z","timestamp":1685325775000},"page":"1283-1292","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Surgical Management of Dupuytren Disease: A Systematic Review and Network Meta-analyses"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-1115","authenticated-orcid":false,"given":"Silas","family":"Nann","sequence":"first","affiliation":[{"name":"The University of Adelaide, SA, Australia"},{"name":"Royal Adelaide Hospital, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kovoor","sequence":"additional","affiliation":[{"name":"The University of Adelaide, SA, Australia"},{"name":"The Queen Elizabeth Hospital, Adelaide, SA, Australia"},{"name":"Royal Australasian College of Surgeons, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Fowler","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kieu","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashray","family":"Gupta","sequence":"additional","affiliation":[{"name":"The University of Adelaide, SA, Australia"},{"name":"The Queen Elizabeth Hospital, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hewitt","sequence":"additional","affiliation":[{"name":"The University of Adelaide, SA, Australia"},{"name":"Royal Adelaide Hospital, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ovenden","sequence":"additional","affiliation":[{"name":"The University of Adelaide, SA, Australia"},{"name":"Royal Adelaide Hospital, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Edwards","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"The University of Adelaide, SA, Australia"},{"name":"The Queen Elizabeth Hospital, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Henry W.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Royal Australasian College of Surgeons, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Harries","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Maddern","sequence":"additional","affiliation":[{"name":"The University of Adelaide, SA, Australia"},{"name":"The Queen Elizabeth Hospital, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2013.03.036"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-01999-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1054\/jhsb.2002.0840"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Riester S van Wijnen A Rizzo M et al. Pathogenesis and treatment of Dupuytren disease. JBJS Rev. 2014;2(4):e2. https:\/\/journals.lww.com\/jbjsreviews\/Fulltext\/2014\/04000\/Pathogenesis_and_Treatment_of_Dupuytren_Disease.2.aspx.","DOI":"10.2106\/JBJS.RVW.M.00072"},{"issue":"46","key":"e_1_3_2_6_2","first-page":"781","article-title":"Dupuytren\u2019s Disease\u2014etiology and treatment","volume":"118","author":"Ruettermann M","year":"2021","unstructured":"Ruettermann M, Hermann RM, Khatib-Chahidi K, et al. Dupuytren\u2019s Disease\u2014etiology and treatment. 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Percutaneous needle fasciotomy versus collagenase treatment for Dupuytren contracture: a randomized controlled trial with a two-year follow-up. JBJS. 2018;100(13): 1079-1086. https:\/\/journals.lww.com\/jbjsjournal\/Fulltext\/2018\/07050\/Percutaneous_Needle_Fasciotomy_Versus_Collagenase.1.aspx.","DOI":"10.2106\/JBJS.17.01128"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Abe Y. Comparison of treatment outcomes after collagenase injection and percutaneous needle fasciotomy for Dupuytren\u2019s contracture: objective and subjective comparisons with a 3-year follow-up. 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