{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:12:40Z","timestamp":1777662760920,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hand (New York, N,Y.)"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dupuytren\u2019s disease (DD) is a progressive fibroproliferative disorder which is, in part, mediated by transforming growth factor beta 1 (TGF-\u03b21). Angiotensin II receptor blockers (ARBs) have been shown to lead to upstream inhibition of TGF-\u03b21 in several disease processes and proposed as a potential pharmacologic treatment in DD. The purpose of this study was to assess the association of ARBs with DD procedures and recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We queried the PearlDiver national insurance dataset to identify patients with a diagnosis of DD and at least 3 years of follow-up. A 1:1 matched cohort was made of patients who were not taking ARBs, and the primary outcome was the rate of index procedures for DD. A second 1:1 matched-control cohort was made among those with an index procedure, to assess for the rate of subsequent procedures as a correlate for revision procedures. We used multivariable logistic regression to assess specific factors associated with initial and subsequent procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The 3-year rate of index procedures was 21.9% in the ARB group and 17.6% in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). The 3-year rate of subsequent procedures was 22.9% in the ARB group and 18.0% in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Angiotensin receptor blockers were independently associated with 1.32 higher odds of an index procedure (95% confidence interval [CI] 1.25-1.40) and 1.35 (95% CI 1.19-1.54) higher odds of a subsequent procedure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although we hypothesized that ARBs would be protective, our findings do not show an association with protection. Instead, the odds ratios suggest a higher risk of index and subsequent procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15589447251343237","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T07:13:52Z","timestamp":1749712432000},"page":"798-805","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiotensin Receptor Blockers Are Not Associated With Protective Benefits in Dupuytren\u2019s Disease"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3775-6664","authenticated-orcid":false,"given":"Daniel A.","family":"Portney","sequence":"first","affiliation":[{"name":"Brown University, Providence, RI, USA"},{"name":"University Orthopedics, East Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6041-2578","authenticated-orcid":false,"given":"Jacob M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Brown University, Providence, RI, USA"},{"name":"University Orthopedics, East Providence, RI, USA"},{"name":"Quinnipiac University, North Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjot","family":"Singh","sequence":"additional","affiliation":[{"name":"Brown University, Providence, RI, USA"},{"name":"University Orthopedics, East Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Brown University, Providence, RI, USA"},{"name":"University Orthopedics, East Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Gil","sequence":"additional","affiliation":[{"name":"Brown University, Providence, RI, USA"},{"name":"University Orthopedics, East Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-010-9306-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-008-9160-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000438455.37604.0f"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2006.08.012"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1200-y"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/17531934221131373"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753193417695996"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000003913"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2023.08.008"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410397971"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73595-y"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753193420903624"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000002739"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2023.02.003"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1530\/EOR-23-0056"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X637055"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13766"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.11.013"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000003476"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21600-w"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211008655"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.11.014"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00266"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516656823"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115291"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2024.103851"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2023.10.015"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003800"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-022-04696-8"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2024.02.035"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001422"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/2000656X.2017.1319846"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsg.2023.06.017"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.08.011"}],"container-title":["HAND"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15589447251343237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15589447251343237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15589447251343237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:30:10Z","timestamp":1777447810000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15589447251343237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/15589447251343237"],"URL":"https:\/\/doi.org\/10.1177\/15589447251343237","relation":{},"ISSN":["1558-9447","1558-9455"],"issn-type":[{"value":"1558-9447","type":"print"},{"value":"1558-9455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,12]]}}}