{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:03:04Z","timestamp":1780992184135,"version":"3.54.1"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hand (New York, N,Y.)"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for type 2 diabetes mellitus (T2DM), yet the perioperative safety profile in hand\/wrist surgery remains incompletely defined. This study evaluated the association between preoperative GLP-1 RA exposure and postoperative complications and healthcare use following operative fixation of distal radius fractures in adults with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cohort study was performed using the TriNetX Network (2018-2024). Adults with T2DM undergoing open surgical fixation of a distal radius fracture were categorized by active GLP-1 RA use within 180 days preoperatively. Propensity score matching (1:1) balanced demographics, fracture complexity, metabolic factors, diabetes severity, and medication use. Outcomes included 90-day medical complications, 180-day surgical complications, and healthcare use through 180 days. Odds ratios with 95% confidence intervals were estimated by logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After matching, 1080 patients (540 per cohort) were included. Glucagon-like peptide-1 receptor agonist use was not associated with significant differences in composite 90-day medical complications or composite 180-day surgical complications. Individual adverse events were uncommon and did not differ between groups. Notably, GLP-1 RA use was associated with lower odds of emergency department visit and\/or inpatient hospital readmission at 180 days, while use at 30 and 90 days was similar between cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Among adults with T2DM undergoing operative fixation of distal radius fractures, preoperative GLP-1 RA exposure was not associated with increased medical or surgical complications and was associated with reduced 180-day healthcare use. These findings support the perioperative safety of GLP-1 RAs in this setting and warrant prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15589447261451445","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:59:18Z","timestamp":1780808358000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Glucagon-Like Peptide-1 Receptor Agonist Use and Postoperative Outcomes After Distal Radius Fracture Fixation in Adults With Type 2 Diabetes"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-9862","authenticated-orcid":false,"given":"Ankit","family":"Choudhury","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4330-8393","authenticated-orcid":false,"given":"Jacob D.","family":"Kodra","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Mathson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Hanley","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"LoGiudice","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor W.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/bot.0000000000000312"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.5435\/jaaos-d-21-00719"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2024.09.014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.j.012802"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.5435\/jaaos-d-24-00915"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2020.08.006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/prs.0000000000006636"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2014.05.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci24-0003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2025.2472408"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/sap.0000000000004089"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.24.01287"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158214"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05929-0"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16136"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsg.2025.100746"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.sart.2024.10.001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2024.07.045"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/15589447251350181"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2024.09.012"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jseint.2024.10.006"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2024.09.057"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2025.08.004"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/mcc.0000000000001294"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2023-221040"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2021.27.4.435"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.10.003"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16541"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.2106\/jbjs.18.00984"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2024-106346"}],"container-title":["HAND"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15589447261451445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15589447261451445","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15589447261451445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:52:50Z","timestamp":1780991570000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15589447261451445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":30,"alternative-id":["10.1177\/15589447261451445"],"URL":"https:\/\/doi.org\/10.1177\/15589447261451445","relation":{},"ISSN":["1558-9447","1558-9455"],"issn-type":[{"value":"1558-9447","type":"print"},{"value":"1558-9455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"article-number":"15589447261451445"}}