{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:13:24Z","timestamp":1788542004800,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hand (New York, N,Y.)"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of trigger finger and are more likely to require operative A1 pulley release. The impact of glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy on treatment progression remains unclear. This study evaluated the association between GLP-1RA use and progression to operative A1 pulley release following corticosteroid injection for trigger finger in patients with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted using the TriNetX Research Network to identify adults with T2DM and trigger finger who underwent an initial corticosteroid injection. Patients were grouped by GLP-1RA exposure and propensity-matched (1:1) for demographics, comorbidities, and other diabetic medications. The primary outcome was A1 pulley release at 6, 12, and 24 months after injection. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated, and balance was assessed using standardized mean differences &lt;0.10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 69\u2009222 patients met inclusion criteria (5871 with GLP-1RA exposure and 63\u2009351 without). After matching, 5863 patients remained in each cohort. Glucagon-like peptide-1 receptor agonist use was not associated with a significant difference in 6-month release rates (6.1% in GLP-1RA users vs 6.8% in nonusers). However, GLP-1RA users had lower release rates at 12 (10.6% vs 11.9%; RR, 0.89; 95% CI, 0.81-0.99;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.027) and 24 months (14.2% vs 15.7%; RR, 0.90; 95% CI, 0.83-0.98;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.016). These differences corresponded to absolute risk reductions of 1.4% and 1.7%, or numbers needed to treat of 71 and 59, at 12 and 24 months, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Glucagon-like peptide-1 receptor agonist therapy was associated with a small but statistically significant reduction in progression to A1 pulley release at 12 and 24 months after corticosteroid injection for trigger finger in patients with T2DM.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Level of evidence<\/jats:bold>\n                      : Level III\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15589447261480181","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:38:22Z","timestamp":1788262702000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["GLP-1 Receptor Agonist Use and A1 Pulley Release After Corticosteroid Injection for Trigger Finger in Type 2 Diabetes"],"prefix":"10.1177","author":[{"given":"Asim A.","family":"Khan","sequence":"first","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyleen","family":"Jan","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-1398","authenticated-orcid":false,"given":"Jason H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6681-4480","authenticated-orcid":false,"given":"Lia","family":"Gaccione-Barreto","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier C.","family":"Simcock","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, 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