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Flow cytometry measurements of T-cell populations and subpopulations and natural killer T cells are performed and levels of G, A, and M immunoglobulins and interleukin 2 (IL-2), IL-4, and interferon \u03b3 were determined. The data interpreted with regard to cumulative doses, length of service, and age. The results of the present study are not enough to outline a clear impact of occupational radiation exposure on T helper populations. Nevertheless, the observed even slight trends in some lymphocyte\u2019s populations and in cytokines profile give us the reason to assume a possibility of a gradual polarization of T helper 1 to T helper 2 immune response at dose range 100 to 200 mSv. The results of the present study indicate the need to perform a more detailed epidemiological survey including potential confounding and misclassifying factors and possible selection bias that could influence the results.<\/jats:p>","DOI":"10.1177\/1559325818785564","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T21:36:40Z","timestamp":1534369000000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of Low-Dose Occupational Exposure to Ionizing Radiation on T-Cell Populations and Subpopulations and Humoral Factors Included in the Immune Response"],"prefix":"10.1177","volume":"16","author":[{"given":"Ilona","family":"Gyuleva","sequence":"first","affiliation":[{"name":"Radiation Medicine and Emergency, National Centre Radiobiology and Radiation Protection, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Djounova","sequence":"additional","affiliation":[{"name":"Radiation Medicine and Emergency, National Centre Radiobiology and Radiation Protection, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanka","family":"Rupova","sequence":"additional","affiliation":[{"name":"Radiation Medicine and Emergency, National Centre Radiobiology and Radiation Protection, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"key":"bibr1-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1080\/0955300021000038662"},{"key":"bibr2-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.06.045"},{"key":"bibr3-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0b013e31824f30e5"},{"issue":"1","key":"bibr4-1559325818785564","first-page":"7","volume":"15","author":"Kusunoki Y","year":"2004","journal-title":"RERF Update"},{"key":"bibr5-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1080\/09553000701616106"},{"key":"bibr6-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00045-6"},{"key":"bibr7-1559325818785564","doi-asserted-by":"publisher","DOI":"10.2174\/092986712800099866"},{"key":"bibr8-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-68943-0"},{"key":"bibr9-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-215228"},{"key":"bibr10-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1667\/RR1847.1"},{"key":"bibr11-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2003)159[0109:LEOTCR]2.0.CO;2"},{"key":"bibr12-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1667\/RR2160.1"},{"key":"bibr13-1559325818785564","first-page":"62","volume-title":"Radiobiological Effects in Occupational Exposure in Nuclear Energy","author":"Gyuleva I","year":"2009"},{"key":"bibr14-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1177\/1559325815611901"},{"key":"bibr15-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1016\/0197-1859(90)90023-2"},{"key":"bibr16-1559325818785564","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00104-5"},{"issue":"2","key":"bibr17-1559325818785564","first-page":"111","volume":"24","author":"Hal\u00e1sz A","year":"2003","journal-title":"Allergy and Asthma Proceedings"},{"key":"bibr18-1559325818785564","unstructured":"Kinnear P, Gray C. 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