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Transforming growth factor 3 ( TGF-\u03b23) is an essential growth factor for palatogenesis. The objective of this study is to clarify the effects of TCDD and TGF-\u03b23 in mouse embryonic palatal mesenchymal (MEPM) cells. The effects of 10 nM TCDD, 10 ng\/mL TGF-\u03b23, or a combination of 10 nM TCDD and 10 ng\/mL TGF-\u03b23 on MEPM cells were revealed by cell and biological methods. With the increase in TCDD (0.5-10 nM), the expression of TGF-\u03b23 increased, but at TCDD concentrations greater than 10 nM, the expression of TGF-\u03b23 reduced. The viabilities of MEPM cells decreased in the 10 nM TCDD-treated group. But the viabilities increased in the 10 ng\/mL TGF-\u03b23-treated group, and the viabilities were intermediate in the group treated with a combination of 10 nM TCDD and 10 ng\/mL TGF-\u03b23. This phenomenon was the same as that of the motilities. In addition, we found that the expression of p-Smad2, p-Smad3,and Smad7 were increased by TCDD, TGF-\u03b23, combination of TCDD and TGF-\u03b23, but the expression of Smad4 were decreased by TCDD, TGF-\u03b23, combination of TCDD and TGF-\u03b23. These data revealed that TCDD and TGF-\u03b23 interacted and affected MEPM cells.<\/jats:p>","DOI":"10.1177\/1559325818786822","type":"journal-article","created":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T23:46:00Z","timestamp":1551656760000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["2,3,7,8-Tetrachlorodibenzo-p-dioxin and\n                    <i>TGF\u03b23<\/i>\n                    -Mediated Mouse Embryonic Palatal Mesenchymal Cells"],"prefix":"10.1177","volume":"17","author":[{"given":"Liyun","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Toxicology, School of Public Health, Xinxiang Medical University, Xinxiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health, Xinxiang Medical University, Xinxiang, 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