{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:33:35Z","timestamp":1791959615444,"version":"4.3.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:p>\n                    To establish a complete technical solution for the automatic radiation biological dose estimation platform for biological dose estimation and classification of the wounded in large-scale radiation accidents, the \u201cdose\u2013effect curve by dicentric chromosome (DIC) automatic analysis\u201d was established and its accuracy was verified. The effects of analyzed cell number and the special treatment of the culture on dose estimation by DIC automatic analysis were studied. Besides, sample processing capabilities of the special equipments were tested. The fitted \u201cdose\u2013effect curve by DIC automatic analysis\u201d was presented as follows: Y = (0.01806 \u00b1 0.00032) D\n                    <jats:sup>2<\/jats:sup>\n                    + (0.01279 \u00b1 0.00084) D + (0.0004891 \u00b1 0.0001358) ( R\n                    <jats:sup>2<\/jats:sup>\n                    = 0.961). Three-gradient scanning method, culture refrigeration method, and interprofessional collaboration under extreme conditions were proposed to improve the detection speed, prolong the sample processing time window, and reduce the equipment investment. In addition, the optimized device allocation ratio for the automatic biological dose estimation laboratory was proposed to eliminate the efficiency bottleneck. The complete set of technical solutions for the high-throughput automatic biological dose estimation laboratory proposed in this study can meet the requirements of early classification and rapid biological dose assessment of the wounded during the large-scale nuclear radiation events, and it is worthy of further promotion.\n                  <\/jats:p>","DOI":"10.1177\/1559325818799951","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T03:39:32Z","timestamp":1538537972000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Complete Technical Scheme for Automatic Biological Dose Estimation Platform"],"prefix":"10.1177","volume":"16","author":[{"given":"Hong","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahui","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, China"},{"name":"Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"bibr1-1559325818799951","doi-asserted-by":"publisher","DOI":"10.1667\/RR1664.1"},{"key":"bibr2-1559325818799951","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(92)90100-V"},{"key":"bibr3-1559325818799951","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncm137"},{"key":"bibr4-1559325818799951","doi-asserted-by":"publisher","DOI":"10.1007\/BF01323412"},{"key":"bibr5-1559325818799951","doi-asserted-by":"publisher","DOI":"10.1667\/RR2321.1"},{"key":"bibr6-1559325818799951","doi-asserted-by":"publisher","DOI":"10.1667\/RR3196.1"},{"key":"bibr7-1559325818799951","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2013.05.013"},{"key":"bibr8-1559325818799951","doi-asserted-by":"publisher","DOI":"10.3109\/09553000903264481"},{"key":"bibr9-1559325818799951","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0b013e3182307758"},{"key":"bibr10-1559325818799951","volume-title":"Radiation Protection \u2013 Performance Criteria for Service Laboratories Performing Biological Dosimetry by Cytogenetics","author":"International Organization for Standardization 19238","year":"2004"},{"issue":"6","key":"bibr11-1559325818799951","first-page":"350","volume":"35","author":"Dai H","year":"2016","journal-title":"Chin J Radiol Med Prot"}],"container-title":["Dose-Response"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1559325818799951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1559325818799951","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1559325818799951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:01:34Z","timestamp":1777399294000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1559325818799951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10,1]]}},"alternative-id":["10.1177\/1559325818799951"],"URL":"https:\/\/doi.org\/10.1177\/1559325818799951","relation":{},"ISSN":["1559-3258","1559-3258"],"issn-type":[{"value":"1559-3258","type":"print"},{"value":"1559-3258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,1]]},"article-number":"1559325818799951"}}