{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:50:38Z","timestamp":1777553438490,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Equipment grant by AlterG Inc. Fremont, CA"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:p>\n                    Lower body positive pressure (LBPP) treadmill activity might benefit patients with heart failure (HF). To determine the short-term effects of LBPP on left ventricular (LV) function in HF patients, LV ejection duration (ED), a measure of systolic function was prospectively assessed in 30 men with stable HF with LV ejection fraction \u2264 40% and 50 healthy men (N). Baseline measurements (100% body weight), including blood pressure (BP), heart rate (HR) and LVED, obtained via radial artery applanation tonometry, were recorded after 2 minutes of standing on weight support treadmill and after LBPP achieving reductions of 25%, 50%, and 75% of body weight in random sequence. Baseline, HR, and LVED (251 \u00b1 5 vs 264 \u00b1 4 ms; P = .035) were lower in the HF group. The LBPP lowered HR more (14% vs 6%, P = .009) and increased LVED more (15% \u00b1 7% vs 10% \u00b1 6%; P = .004) in N versus HF. Neither group had changes (\u0394) in BP. On generalized linear regression, the 2 groups showed different responses ( P &lt; .001). Multivariate analysis showed %\u0394HR ( P &lt; .001) and HF ( P = .026) were predictive of \u0394ED ( r\n                    <jats:sup>2<\/jats:sup>\n                    = 0.44; P &lt; .001). In conclusion, progressive LBPP increases LVED in a step-wise manner in N and HF patients independent of HR lowering. The \u0394LVED is less marked in patients with HF.\n                  <\/jats:p>","DOI":"10.1177\/1559325818811543","type":"journal-article","created":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T21:05:35Z","timestamp":1543179935000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Lower Body Positive Pressure on Left Ventricular Ejection Duration in Patients With Heart Failure"],"prefix":"10.1177","volume":"16","author":[{"given":"Sriya","family":"Avadhani","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Ihsan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, 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