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Therefore, exploring new strategies with better therapeutic outcomes and lower incidences of unfavorable side effect is imperative. Recently, exosomes, secreted microvesicles of endocytic origin, have caught researcher\u2019s eyes in tissue regeneration fields, especially in cartilage and bone-related regeneration. Multiple researchers have demonstrated the crucial roles of exosomes throughout every developing stage of cartilage and bone tissue regeneration, indicating that there may be a potential therapeutic application of exosomes in future clinical use. Herein, we summarize the function of exosomes derived from the primary cells functioning in skeletal diseases and their restoration processes, therapeutic exosomes used to promote cartilage and bone repairing in recent research, and applications of exosomes within the setting of the TE matrix.<\/jats:p>","DOI":"10.1177\/1559325819892702","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T21:34:03Z","timestamp":1576272843000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["Exosomes: A Novel Therapeutic Agent for Cartilage and Bone Tissue Regeneration"],"prefix":"10.1177","volume":"17","author":[{"given":"Yanxin","family":"Liu","sequence":"first","affiliation":[{"name":"Engineering Research Center for Biomaterials of Ministry of Education, East China University of Science and Technology, Shanghai, People\u2019s Republic of China"},{"name":"Key Laboratory for Ultrafine 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