{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:52:31Z","timestamp":1777553551667,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To establish a complete technical solution for the radiation biological dose estimation, to enable prediction of individuals\u2019 response to radiotherapy (RT), and to control treatment dose for reduced irradiation injury and promote repair; and to evaluate the risk of radiation-induced late effects for patients undergoing external photon beam RT and provide the reliable dose\u2013response relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Select 49 tumor patients using\n                      <jats:sup>60<\/jats:sup>\n                      Co and linear accelerator for radiation therapy; initial radiation dose was 250 cGy. Chromosome aberration and blood count were analyzed before radiation therapy and 2 hours after the first day of RT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Two hours after the first day of RT, peripheral blood cell count of lymphocytes of patients with cancer was significantly decreased ( P &lt; .01). The frequency of chromosome aberration was higher ( P &lt; .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>High-dose radiation of the radiation therapy makes significant injuries to peripheral blood lymphocytes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1559325820913360","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T06:00:18Z","timestamp":1585548018000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Study of Indicators for Early and Rapid Diagnosis of Radiation Injury Is the Most Important in Patients With Cancer During Radiotherapy"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3153-7797","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"first","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Mei","family":"Niu","sequence":"additional","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Qin","family":"Wu","sequence":"additional","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"bibr1-1559325820913360","author":"IAEA","year":"2001","journal-title":"Cytogenetic analysis for radiation dose assessment"},{"key":"bibr2-1559325820913360","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2199-z"},{"key":"bibr3-1559325820913360","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318145b2c6"},{"key":"bibr4-1559325820913360","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-018-01419-0"},{"key":"bibr5-1559325820913360","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.77"},{"key":"bibr6-1559325820913360","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-199101000-00010"},{"key":"bibr7-1559325820913360","doi-asserted-by":"publisher","DOI":"10.1080\/09553000210152953"},{"issue":"1","key":"bibr8-1559325820913360","first-page":"34","volume":"17","author":"Jin CZ","year":"1997","journal-title":"Chin J Radiol Med Prot"},{"key":"bibr9-1559325820913360","unstructured":"Jin CZ, Liu XL. Biological Dose Estimation of Cases Who Were Exposed to\n                      60\n                      Co Source in Shanghai \u201c6.25\u201d Radiation Accident\/\/Liu BC, Ye GY. Corpus of Diagnosis and Treatment for Cases Who Were Exposed to\n                      60\n                      Co Source in Shanghai \u201c6.25\u201d Radiation Accident. Beijing, China: Science and Technology Press, 1994:26."},{"key":"bibr10-1559325820913360","volume-title":"GB\/T 28236-2011 Method of Chromosome Aberration Analysis for Biological Dose Assessment(s)","author":"Ministry of Health of the people\u2019s Republic of China","year":"2011"},{"issue":"2","key":"bibr11-1559325820913360","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1088\/0952-4746\/26\/2\/E02","volume":"26","author":"Ying C","year":"2006","journal-title":"Chin J Radiol Med Prot"},{"key":"bibr12-1559325820913360","unstructured":"Liu SZ. Medical Radiobiology. Beijing, China: Atomic Energy Press; 2006:125\u2013128."},{"issue":"1","key":"bibr13-1559325820913360","first-page":"81","volume":"32","author":"Wang YY","year":"2013","journal-title":"Chin J Radiol Med Prot"},{"key":"bibr14-1559325820913360","doi-asserted-by":"publisher","DOI":"10.1186\/cc9309"},{"key":"bibr15-1559325820913360","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.11.005"},{"key":"bibr16-1559325820913360","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.08.011"},{"key":"bibr17-1559325820913360","doi-asserted-by":"publisher","DOI":"10.31768\/2312-8852.2015.37(2):89-93"}],"container-title":["Dose-Response"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1559325820913360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1559325820913360","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1559325820913360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:02:09Z","timestamp":1777399329000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1559325820913360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"alternative-id":["10.1177\/1559325820913360"],"URL":"https:\/\/doi.org\/10.1177\/1559325820913360","relation":{},"ISSN":["1559-3258","1559-3258"],"issn-type":[{"value":"1559-3258","type":"print"},{"value":"1559-3258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"article-number":"1559325820913360"}}