{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:37:02Z","timestamp":1782139022017,"version":"3.54.5"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:p>Elevated inflammatory cytokines and high mobility group box 1 (HMGB1) production are associated with chronic periodontitis (CP). Glycyrrhizin is the major constituent of Glycyrrhiza glabra. L. (Fabaceae) root with anti-inflammation activities. This study evaluated the effects of glycyrrhizin on CP. TNF-\u03b1-treated human periodontal ligament stem cell (hPDLSC) model was established, and was administrated with 1, 2 or 5 mM glycyrrhizin for 24 h. After treatment, the expression of HMGB1and inflammatory cytokines was monitored. Significantly increased HMGB1 (median: 5646.4, range: 1918.2-8233.7 vs median: 204.5, range: 98.7-283.6, pg\/mL), TNF-\u03b1 (median: 345.5, range: 161.0-567.9 vs median: 93.5, range: 58.1-159.3, pg\/mL), IL-1\u03b2 (median: 2014.6, range: 209.5-4308.1 vs median: 224.5, range: 48.8-335.8, pg\/mL) and IL-6 (median: 1223.6, range: 398.2-2183.8 vs median: 240.4, range: 105.2-400.5, pg\/mL) were detected in gingival crevicular fluid from CP patients. Glycyrrhizin significantly prevented TNF-\u03b1-induced expression of HMGB1 (691.5 \u00b1 136.4 vs 142.8 \u00b1 57.3 pg\/mL), IL-6 (388.1 \u00b1 85.2 vs 189.4 \u00b1 61.2 pg\/mL) and IL-1\u03b2 (176.3 \u00b1 47.2 vs 53.9 \u00b1 25.7 pg\/mL) in hPDLSC. In CP rats, glycyrrhizin significantly decreased HMGB1 (5795.6 \u00b1 1121.5 vs 586.4 \u00b1 436.8 pg\/mL), TNF-\u03b1 (421.8 \u00b1 93.7 vs 87.9 \u00b1 21.6 pg\/mL), IL-6 (1423.8 \u00b1 235.2 vs 622.6 \u00b1 176.1 pg\/mL) and IL-1\u03b2 (1562.8 \u00b1 334.3 vs 733.5 \u00b1 265.1 pg\/mL) in gingival crevicular fluid. Glycyrrhizin suppresses inflammatory activities in CP rats and represents a promising molecule for controlling CP.<\/jats:p>","DOI":"10.1177\/1559325820952660","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T22:35:10Z","timestamp":1599777310000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Beneficial Effects of Glycyrrhizin in Chronic Periodontitis Through the Inhibition of Inflammatory Response"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4112-5646","authenticated-orcid":false,"given":"Yaru","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Stomatology Clinic, Cangzhou Central Hospital, Cangzhou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery, Cangzhou Central Hospital, Cangzhou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaobao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Clinic, Cangzhou Central Hospital, Cangzhou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Stomatology Clinic, Cangzhou Central Hospital, Cangzhou, Hebei, 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