{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:07:57Z","timestamp":1780434477723,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172593, 81573081, 81803162, 82003393 and 82173463"],"award-info":[{"award-number":["81172593, 81573081, 81803162, 82003393 and 82173463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to analyze the alteration of carnitine profile in the small intestine of abdominal irradiation-induced intestinal injury rats and explore the possible reason for the altered carnitine profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The abdomens of 15 male Sprague Dawley (SD) rats were irradiated with 0, 10, and 15\u00a0Gy of\n                      <jats:sup>60<\/jats:sup>\n                      Co gamma rays. The carnitine profile in the small intestine and plasma samples of SD rats at 72\u00a0h after abdominal irradiated with 0\u00a0Gy or 10\u00a0Gy of\n                      <jats:sup>60<\/jats:sup>\n                      Co gamma rays were measured by targeted metabolomics. The changes of fatty acid \u03b2-oxidation (FAO), including the expression of carnitine palmitoyltransferase 1 (CPT1) and acyl-CoA dehydrogenases, were analyzed in the small intestine samples of SD rats after exposed to 0, 10, and 15\u00a0Gy groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were eleven acylcarnitines in the small intestine and fourteen acylcarnitines in the plasma of the rat model significantly enhanced, respectively (P &lt; .05). The expression level and activity of CPT1 in the small intestine were remarkably increased (P &lt; .05), and the activity of acyl-CoA dehydrogenase in the small intestine was noticeably reduced (P &lt; .01) after abdominal irradiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The enhanced acylcarnitine levels in the small intestine of abdominal irradiation rats might relate to the FAO pathway disequilibration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258221075118","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T21:07:50Z","timestamp":1645564070000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Enhancement of Acylcarnitine Levels in Small Intestine of Abdominal Irradiation Rats Might Relate to Fatty Acid \u03b2-Oxidation Pathway Disequilibration"],"prefix":"10.1177","volume":"20","author":[{"given":"Hai-Xiang","family":"Liu","sequence":"first","affiliation":[{"name":"China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Lu","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-9073","authenticated-orcid":false,"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, 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