{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:06:03Z","timestamp":1787169963958,"version":"build-2736575974"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12065001"],"award-info":[{"award-number":["12065001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology National Key R&D project","award":["2018YFE020524"],"award-info":[{"award-number":["2018YFE020524"]}]},{"name":"Lanzhou Heavy Ion Accelerated HIRFL user Cultivation project","award":["HIR19PY008"],"award-info":[{"award-number":["HIR19PY008"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    To explore the effect of high-LET carbon ion (C-ion) radiation on malignant melanoma, we systematically compared the radiobiological effects of C-ion with that of X-rays in B16F10 melanoma cells. Results showed that C-ion radiation statistically inhibited clonogenic survival capacity of B16F10 melanoma cells. The RBE was 3.7 at D\n                    <jats:sub>10<\/jats:sub>\n                    levels, meaning 1.0\u00a0Gy C-ion should cause the same biological effect as \u2265 3.0\u00a0Gy X-rays. In addition, we also observed a stronger proliferation-inhibiting and higher ratio of cell apoptosis and necrosis in B16F10 cells treated with C-ion than X-rays. Moreover, C-ion radiation exhibited stronger and long-lasting G2\/M arrest than X-rays. As an underlying mechanism, we speculated that C-ion radiation-induced G2\/M block through activating pRb\/E2F1\/Chk2 pathway. With these results, we highlighted the potential of C-ion in treatment of cutaneous melanoma. Further, in vitro experiments as well as clinical trials are needed to further evaluate the effect of carbon ion radiotherapy in melanoma.\n                  <\/jats:p>","DOI":"10.1177\/15593258221092364","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T21:27:46Z","timestamp":1649453266000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Carbon Ion Induces Cell Death and G2\/M Arrest Through pRb\/E2F1Chk2\/Cdc2 Signaling Pathway in X-ray Resistant B16F10 Melanoma Cells"],"prefix":"10.1177","volume":"20","author":[{"given":"Sha","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The 940th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Lanzhou, 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