{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:11:28Z","timestamp":1790993488520,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy and safety of baricitinib, a Janus kinase (JAK) inhibitor, in treating patient with progressing vitiligo, and to further explore the regulation of baricitinib on melanocytes (MCs) in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Four patients with progressing vitiligo were treated with oral baricitinib for a total of 12\u00a0weeks. MCs were cultured in vitro and irradiated by high-dose ultraviolet B (UVB, 150mJ\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ) to make an MC damaged model (MC-Ds). Baricitinib was added at a final concentration of 25\u00a0\u03bcM. Dopamine staining and NaOH method were used to measure the tyrosinase activity and melanin level, respectively, real-time quantitative polymerase chain reaction (RT-qPCR) was used to measure the mRNA levels of tyrosinase (TYR), tyrosinase-related protein-1 (TRP-1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant re-pigmentation was observed in the week 12 without obvious side effects. Depigmentation occurred in 2 patients at the 3-month follow-up. Laboratory research found that higher doses of UVB irradiation (150mJ\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ) could decrease melanin content of MCs, baricitinib (25\u00a0\u03bcM) could significantly promote tyrosinase activity, melanin content, and TYR, TRP-1 gene expression of MC-Ds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our preliminary study showed that baricitinib was effective and safe in treating progressing vitiligo. Baricitinib could promote tyrosinase activity, melanin content and TYR, TRP1 gene expression of MC-Ds in vitro.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258221105370","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T12:16:46Z","timestamp":1653999406000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Baricitinib is Effective in Treating Progressing Vitiligo in vivo and in vitro"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-3803","authenticated-orcid":false,"given":"Jie","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ping","family":"Ma","sequence":"additional","affiliation":[{"name":"China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Nian","family":"Wang","sequence":"additional","affiliation":[{"name":"PLA Rocket Force Characteristic Medical Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"PLA Rocket Force Characteristic Medical Center, 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Evaluation of Effect and Tolerance of the Association of Baricitinib and Phototherapy Versus Phototherapy in Adults with Progressive Vitiligo (BARVIT). Bethesda, MD: U.S.National Library of Medicine, ClinicalTrials.gov. 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