{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:54:57Z","timestamp":1783346097233,"version":"3.54.6"},"reference-count":90,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    The present study aims to evaluate the protective effect of Crataegus azarolus berries decoction extract (CAB-DE) against acetic acid-induced ulcerative colitis as well as the mechanisms implicated in such protection. Adult male Wistar rats were separated into seven groups: Control (H\n                    <jats:sub>2<\/jats:sub>\n                    O), acetic acid (AA), AA + various doses of CAB-DE (100, 200, and 400\u00a0mg\/kg, b.w.,p.o.), and AA + sulfasalazine (100\u00a0mg\/kg, b.w.,p.o.) or gallic acid (50\u00a0mg\/kg, b.w.,p.o.) during 10\u00a0days. All rats were kept fasting overnight and ulcerative colitis was induced by rectal infusion of AA (300\u00a0mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , b.w.) (3%, v\/v, 5\u00a0mL kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    b.w), for 30\u00a0s. The colon was rapidly excised and macroscopically examined to measure ulcerated surfaces and the ulcer index. In vitro, we found that CAB-DE exhibited a high antioxidant activity against DPPH radical (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 164.17 \u00b1 4.78\u00a0\u03bcg\/mL). In vivo , pretreatment with CAB-DE significantly protected the colonic mucosa against AA-induced damage by stimulating mucus secretion, reducing ulcer index as well as histopathological changes. Also, CAB-DE limited the oxidative status induced by AA in the colonic mucosa, as assessed by MDA and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    increased levels and the depletion of both enzymatic activities and non-enzymatic levels. In addition, AA intoxication increased iron and calcium levels in colonic mucosa and plasma, while CAB-DE pretreatment regulated all intracellular mediators deregulation and significantly reduced inflammatory markers such as CRP (1.175 \u00b1 .04 \u2500 .734 \u00b1 .06\u00a0\u03bcg\/dl) and ALP (161.53 \u00b1 5.02 \u2500 98.60 \u00b1 4.21 UI\/L) levels. We suggest that CAB-DE protected against AA-induced ulcerative colitis due in part to its antioxidant and anti-inflammatory properties.\n                  <\/jats:p>","DOI":"10.1177\/15593258241226890","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T01:58:31Z","timestamp":1704938311000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Phytochemical Properties of\n                    <i>Crataegus azarolus<\/i>\n                    Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-4098","authenticated-orcid":false,"given":"Houcem","family":"Sammari","sequence":"first","affiliation":[{"name":"Institut Sup\u00e9rieur de Biotechnologie de Beja, Universit\u00e9 de Jendouba, Beja, Tunisie"},{"name":"Universit\u00e9 de Jendouba, Institut Sylvo-Pastoral de Tabarka, Tabarka, Tunisie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5405-8385","authenticated-orcid":false,"given":"Saber","family":"Jedidi","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur de Biotechnologie de Beja, Universit\u00e9 de Jendouba, Beja, Tunisie"},{"name":"Universit\u00e9 de Jendouba, Institut Sylvo-Pastoral de Tabarka, Tabarka, Tunisie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6974-6973","authenticated-orcid":false,"given":"Houcine","family":"Selmi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Jendouba, Institut Sylvo-Pastoral de Tabarka, Tabarka, Tunisie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Jridi","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur de Biotechnologie de Beja, Universit\u00e9 de Jendouba, Beja, Tunisie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Ayari","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur de Biotechnologie de Beja, Universit\u00e9 de Jendouba, Beja, Tunisie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hichem","family":"Sebai","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur de Biotechnologie de Beja, Universit\u00e9 de Jendouba, Beja, Tunisie"},{"name":"Ecole Nationale de M\u00e9decine V\u00e9t\u00e9rinaire de Sidi Thabet, Universit\u00e9 de la Manouba, Manouba, Tunisie"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"bibr1-15593258241226890","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814700-9.00007-8"},{"key":"bibr2-15593258241226890","unstructured":"Carillon A. 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