{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:54:55Z","timestamp":1777553695019,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["NO: 2022xkj247"],"award-info":[{"award-number":["NO: 2022xkj247"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Anhui Education","award":["NO: 2022AH052555"],"award-info":[{"award-number":["NO: 2022AH052555"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    The incidence of emergence delirium (ED) is higher in preschool children undergoing tonsillectomy and\/or adenoidectomy. The purpose of this study was to determine the median effective dose (ED50) of dexmedetomidine (DEX) for the inhibition of ED in preschool children by using probit regression analysis. A total of 140 anesthesia records were retrieved and divided into seven groups based on the infusion rate of DEX: .2, .25, .3, .35, .4, .45, and .5\u00a0\u03bcg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The Pediatric Anesthesia Emergence Delirium Scale (PAEDS) was used to assess ED in preschool children, and ED was defined as a PAEDS score \u2265 10. Probit regression analysis revealed that the ED50 and ED95 of DEX were .31\u00a0\u03bcg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    (95% CI: .29\u2013.35) and .48\u00a0\u03bcg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    (95% CI: .44\u2013.56), respectively. Probit(p) = \u22122.84 + 9.28 \u00d7 ln (Dose), (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    = 1.925,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .859). The PAEDS score was significantly increased in the ED group, and the rate of bradycardia was significantly decreased in the ED group compared with the without ED group (27.3% vs 54.1%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .02). DEX can effectively inhibit the ED in preschool children undergoing tonsillectomy and\/or adenoidectomy, however, bradycardia was the main complication.\n                  <\/jats:p>","DOI":"10.1177\/15593258241248919","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T02:17:02Z","timestamp":1713579422000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Median Effective Dose of Dexmedetomidine for the Inhibition of Emergence Delirium in Preschool Children Undergoing Tonsillectomy and\/or Adenoidectomy: A Retrospective Dose-response Trial"],"prefix":"10.1177","volume":"22","author":[{"given":"BaiYun","family":"Wei","sequence":"first","affiliation":[{"name":"The Medical Center of AnQing of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CuiYu","family":"Yu","sequence":"additional","affiliation":[{"name":"The Medical Center of AnQing of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JinBo","family":"Xiao","sequence":"additional","affiliation":[{"name":"The Medical Center of AnQing of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang","family":"Xu","sequence":"additional","affiliation":[{"name":"The Medical Center of AnQing of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Medical Center of AnQing of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6059-7916","authenticated-orcid":false,"given":"WeiBing","family":"Wang","sequence":"additional","affiliation":[{"name":"The Medical Center of AnQing of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2015.8.1.46"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2012.63.1.48"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12287"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31816c8929"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03021583"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.00940.x"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep376"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12587"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.022"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(11)12"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.04.027"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000931"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/2279-042X.150051"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_419_17"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.304"},{"issue":"6","key":"e_1_3_6_17_2","first-page":"2863","article-title":"Consciousness inhibition of intravenous dexmedetomidine in patients undergoing lower limb surgery with epidural anesthesia: a dose-response study by age group","volume":"31","author":"Sun Q","year":"2018","unstructured":"Sun Q, Wang X, Shi C, et al. 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