{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:10:05Z","timestamp":1789229405173,"version":"build-2803163510"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Scientific research project of universities in Inner Mongolia Autonomous Region","award":["NJZZ23104"],"award-info":[{"award-number":["NJZZ23104"]}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2020MS08071"],"award-info":[{"award-number":["2020MS08071"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2020MS08077"],"award-info":[{"award-number":["2020MS08077"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2021MS08126"],"award-info":[{"award-number":["2021MS08126"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2022LHMS08011"],"award-info":[{"award-number":["2022LHMS08011"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260808"],"award-info":[{"award-number":["82260808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region","award":["NJYT23112"],"award-info":[{"award-number":["NJYT23112"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute lung injury (ALI) is a serious illness that has few treatment options available. Tribuloside, a natural flavonoid extracted from the Tribulus Terrestris plant in China, is potent in addressing many health issues such as headaches, dizziness, itching, and vitiligo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study intends to explore the mechanisms of action of Tribuloside in treating ALI through a combination of network pharmacology and experimental validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We obtained the 2D structure and SMILES number of Tribuloside from the PubChem database. We used the SwissTargetPrediction database to identify pharmacological targets. We found 1215 targets linked to ALI by examining the GeneCards database. We used the String database and Cytoscape software to create the \u201cdrug or disease-target\u201d network as well as the protein-protein interactions (PPI). Key targets were identified by evaluating associated biological processes and pathway enrichment. A Venny Diagram showed 49 intersection points between Tribuloside and ALI. Molecular docking with AutoDockTools found that Tribuloside had a high affinity for IL6, BCL2, TNF, STAT3, IL1B, and MAPK3, the top 6 targets in the PPI network by Degree values. To test Tribuloside\u2019s therapeutic efficacy in ALI, an acute lung damage model in mice was constructed using lipopolysaccharide. Tribuloside treatment reduced inflammatory cell infiltration, decreased fibrotic area, repaired damaged alveoli, and suppressed inflammatory factors IL-6, TNF-\u03b1, and IL-1\u03b2 in the lungs through many pathways and targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals that Tribuloside has the potential to treat ALI by targeting various pathways and targets, according to network pharmacology predictions and experimental confirmation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258241251594","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T03:42:23Z","timestamp":1715139743000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Tribuloside: Mechanisms and Efficacy in Treating Acute Lung Injury Revealed by Network Pharmacology and Experimental Validation"],"prefix":"10.1177","volume":"22","author":[{"given":"Zheng","family":"Yang","sequence":"first","affiliation":[{"name":"Baotou Medical College, Baotou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2426-5193","authenticated-orcid":false,"given":"Tiantian","family":"Hao","sequence":"additional","affiliation":[{"name":"Baotou Medical College, Baotou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbing","family":"Ma","sequence":"additional","affiliation":[{"name":"Baotou Medical College, Baotou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"Baotou Medical College, Baotou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Qiu","sequence":"additional","affiliation":[{"name":"Baotou Medical College, Baotou, China"},{"name":"Inner Mongolia Agricultural University, Hohhot, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Agricultural University, Hohhot, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"issue":"5","key":"bibr1-15593258241251594","doi-asserted-by":"crossref","first-page":"100777","DOI":"10.1016\/j.cpsurg.2020.100777","volume":"57","author":"Mowery NT","year":"2020","journal-title":"Curr Probl Surg"},{"issue":"3","key":"bibr2-15593258241251594","first-page":"S353","volume":"69","author":"Mokr\u00e1 D","year":"2020","journal-title":"Physiol Res"},{"key":"bibr3-15593258241251594","doi-asserted-by":"crossref","first-page":"584514","DOI":"10.3389\/fimmu.2020.584514","volume":"11","author":"Lupu L","year":"2020","journal-title":"Front 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