{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:25:36Z","timestamp":1790727936568,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cyperus rotundus L., commonly known as nutsedge or purple nutgrass, is a resilient herb in the Cyperaceae family with notable pharmacological potential due to its diverse secondary metabolites. This study aimed to identify these metabolites and evaluate the antioxidant and enzyme inhibitory activities of the crude methanol extract of C. rotundus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The crude methanol extract of C. rotundus was prepared, and its antioxidant activity was assessed using the DPPH scavenging assay. Additionally, in vitro inhibitory effects against the enzymes: \u03b1-amylase and \u03b1-glucosidase were evaluated. The secondary metabolites present in the extract were identified using ESI-MS\/MS analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ESI-MS\/MS analysis revealed the presence of various secondary metabolites, including rutin, quercetin, \u03b2-sitosterol, limonene, and beta-pinene. The crude methanol extract exhibited strong antioxidant activity and significant inhibition of \u03b1-amylase and \u03b1-glucosidase enzymes, which play crucial roles in carbohydrate digestion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings indicate that the crude methanol extract of C. rotundus possesses notable antioxidant properties and the potential to inhibit key enzymes involved in carbohydrate metabolism. This study enhances our understanding of the bioactive compounds in C. rotundus and suggests its therapeutic applications for managing conditions related to carbohydrate metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258241308724","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T11:23:48Z","timestamp":1734002628000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Identification of Secondary Metabolites of\n                    <i>Cyperus rotundus<\/i>\n                    L. and Dose-dependent Effects on Antioxidant Activity and Carbohydrate Digestion Enzymes"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-5233","authenticated-orcid":false,"given":"Muhammad Sajid Hamid","family":"Akash","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammara","family":"Afzaal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanwal","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Women University, Multan, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-7580","authenticated-orcid":false,"given":"Amjad","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Okara, Okara, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Government College University, Faisalabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Muhammad","family":"Shoaib","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Bahauddin Zakariya University, Multan, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudassar","family":"Shahid","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Sadaf","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"bibr1-15593258241308724","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2004.11.011"},{"key":"bibr2-15593258241308724","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3345"},{"issue":"1","key":"bibr3-15593258241308724","first-page":"76","volume":"59","author":"Gupta M","year":"1971","journal-title":"Indian J Med Res"},{"key":"bibr4-15593258241308724","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00221-5"},{"key":"bibr5-15593258241308724","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960984"},{"key":"bibr6-15593258241308724","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199708)11:5<392::AID-PTR113>3.0.CO;2-1"},{"key":"bibr7-15593258241308724","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8524(99)00103-0"},{"issue":"1","key":"bibr8-15593258241308724","first-page":"43","volume":"16","author":"Akperbekova B","year":"1967","journal-title":"Farmatsiya"},{"key":"bibr9-15593258241308724","unstructured":"Dutta S, Mukerji B, Douglas C. 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