{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:50:38Z","timestamp":1779288638708,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Anhui Health Research Project","award":["AHWJ2023BAA10016"],"award-info":[{"award-number":["AHWJ2023BAA10016"]}]},{"name":"Provincial Quality Engineering Project of Higher Education Institutions","award":["2022ZYRC01"],"award-info":[{"award-number":["2022ZYRC01"]}]},{"name":"Wannan Medical College Teaching Quality and Teaching Reform Project","award":["2022ZYRC103"],"award-info":[{"award-number":["2022ZYRC103"]}]},{"DOI":"10.13039\/501100014980","name":"WANNAN Medical College","doi-asserted-by":"crossref","award":["Y23062"],"award-info":[{"award-number":["Y23062"]}],"id":[{"id":"10.13039\/501100014980","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To evaluate the influencing factors of Vancomycin trough concentration in blood, construct an individualized Vancomycin administration model for rational use of Vancomycin.\n                    <jats:bold>Methods:<\/jats:bold>\n                    The clinical data of Vancomycin trough concentration in blood from June 2020 to December 2022 in our hospital were analyzed retrospectively. The effects of age, sex, Vancomycin administration and cumulative dose, albumin, total bilirubin, alanine aminotransferase, Creatinine (CR), urea (Bun), Creatinine clearance rate (Ccr), and time of blood sample collection on Vancomycin trough concentration were analyzed. A linear regression equation for the influencing factors of Vancomycin trough concentration in blood was constructed.\n                    <jats:bold>Results:<\/jats:bold>\n                    Sixty-six\u00a0patients (82.5%) were treated with Vancomycin by intravenous drip. Significant differences existed in the influence of patients\u2019 age, Vancomycin administration, CR, Bun and Ccr on Vancomycin trough concentration (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). Vancomycin trough concentration in blood showed negative correlated with Ccr (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). The regression model of Vancomycin trough concentration in blood was y = 40.911 - 10.971 \u00d7 method of administration - 1.715 \u00d7 collection time + 1.018 \u00d7 cumulative dose - 0.178 \u00d7 Ccr, the model could predict 41.30% Vancomycin trough concentration in blood.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The influencing factors of Vancomycin trough concentration in blood were complex. The constructed regression model of Vancomycin concentration in plasma may provide a scientific reference for individualized administration of Vancomycin in clinical practice.\n                  <\/jats:p>","DOI":"10.1177\/15593258251313646","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T06:45:41Z","timestamp":1745390741000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple linear regression model was constructed based on the influencing factors of vancomycin trough concentration"],"prefix":"10.1177","volume":"23","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"The Department of Pharmaceutical Management, The First Affiliated Hospital of Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhuang","family":"Wang","sequence":"additional","affiliation":[{"name":"The Department of Biochemistry and Molecular Biology, Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Yang","sequence":"additional","affiliation":[{"name":"The Department of Pharmaceutical Management, The First Affiliated Hospital of Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Department of Pharmaceutical Management, The First Affiliated Hospital of Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Wang","sequence":"additional","affiliation":[{"name":"The Department of Pharmaceutical Management, The First Affiliated Hospital of Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-3669","authenticated-orcid":false,"given":"Mingcai","family":"Wu","sequence":"additional","affiliation":[{"name":"The Department of Biochemistry and Molecular Biology, Wannan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00107"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000974"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piad032"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr5238"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106728"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000531638"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0634-8"},{"issue":"3","key":"e_1_3_4_9_2","first-page":"277","article-title":"Analysis of continuous and intermittent infusion of Vancomycin in critically ill patients","volume":"22","author":"Li MJ","year":"2022","unstructured":"Li MJ, Lu ZH, Yang X, et al. Analysis of continuous and intermittent infusion of Vancomycin in critically ill patients. Chin J Infect Chemother. 2022;22(3):277-281.","journal-title":"Chin J Infect Chemother"},{"issue":"8","key":"e_1_3_4_10_2","first-page":"76","article-title":"A comprehensive analysis of the efficacy and adverse reactions of high and low Vancomycin concentrations in patients with severe respiratory tract infections","volume":"34","author":"Chen J","year":"2022","unstructured":"Chen J. A comprehensive analysis of the efficacy and adverse reactions of high and low Vancomycin concentrations in patients with severe respiratory tract infections. Straits Phar. 2022;34(8):76-77.","journal-title":"Straits Phar"},{"issue":"3","key":"e_1_3_4_11_2","first-page":"281","article-title":"Relationship between serum Vancomycin concentration and clinical efficacy and acute renal injury","volume":"42","author":"Li Y","year":"2021","unstructured":"Li Y, Wang XB, Chen LZ, et al. Relationship between serum Vancomycin concentration and clinical efficacy and acute renal injury. J Second Military Med U. 2021;42(3):281-286.","journal-title":"J Second Military Med U"},{"issue":"2","key":"e_1_3_4_12_2","first-page":"468","article-title":"Analysis of influencing factors on plasma drug concentration in peritoneal dialysis-associated peritonitis patients after Vancomycin intraperitoneal administration","volume":"20","author":"Yang W","year":"2022","unstructured":"Yang W, Huang HH, Xiong HY, et al. Analysis of influencing factors on plasma drug concentration in peritoneal dialysis-associated peritonitis patients after Vancomycin intraperitoneal administration. Zhongnan Pharma. 2022;20(2):468-472.","journal-title":"Zhongnan Pharma"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.773994"},{"issue":"9","key":"e_1_3_4_14_2","first-page":"1093","article-title":"Monitoring of plasma trough concentration of Vancomycin in the treatment of methicillin-resistant Staphylococcus aureus infections and evaluation of its efficacy","volume":"22","author":"Liu YN","year":"2022","unstructured":"Liu YN, Li XF, Tang JH, et al. Monitoring of plasma trough concentration of Vancomycin in the treatment of methicillin-resistant Staphylococcus aureus infections and evaluation of its efficacy. Eval An Drug Chinese Hosp. 2022;22(9):1093-1097.","journal-title":"Eval An Drug Chinese Hosp"},{"issue":"6","key":"e_1_3_4_15_2","first-page":"486","article-title":"Correlation between Vancomycin intraperitoneal drug concentrations and plasma drug concentrations in patients with peritoneal dialysis-associated peritonitis","volume":"57","author":"Bian YC","year":"2022","unstructured":"Bian YC, Yao CC, Ishitate, et al. Correlation between Vancomycin intraperitoneal drug concentrations and plasma drug concentrations in patients with peritoneal dialysis-associated peritonitis. Chin J Pharm. 2022;57(6):486-490.","journal-title":"Chin J Pharm"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13091378"},{"issue":"11","key":"e_1_3_4_17_2","first-page":"1674","article-title":"Analysis of the influence of postoperative intracranial infection on plasma Vancomycin concentration in patients with severe craniocerebral injury","volume":"18","author":"Shen LN","year":"2021","unstructured":"Shen LN. Analysis of the influence of postoperative intracranial infection on plasma Vancomycin concentration in patients with severe craniocerebral injury. Anti-infect Pharm. 2021;18(11):1674-1677.","journal-title":"Anti-infect Pharm"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05067-7"},{"issue":"10","key":"e_1_3_4_19_2","first-page":"18","article-title":"Effect of albumin level on serum Vancomycin concentration in children with hypoalbuminemia","volume":"27","author":"Long YY","year":"2021","unstructured":"Long YY, Zhang XJ, Li HY. Effect of albumin level on serum Vancomycin concentration in children with hypoalbuminemia. J Pediatr Pharm. 2021;27(10):18-21.","journal-title":"J Pediatr Pharm"},{"issue":"10","key":"e_1_3_4_20_2","first-page":"190","article-title":"Effects of different Vancomycin doses on blood drug concentration in the elderly","volume":"18","author":"Chen JQ","year":"2021","unstructured":"Chen JQ, Hong XJ. Effects of different Vancomycin doses on blood drug concentration in the elderly. Northern Pharm. 2021;18(10):190-191.","journal-title":"Northern Pharm"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-021-00705-0"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00333-24"},{"issue":"17","key":"e_1_3_4_23_2","first-page":"4226","article-title":"Correlation of Vancomycin concentration with clinical outcome and nephrotoxicity in elderly patients with deep infection","volume":"42","author":"Zou T","year":"2022","unstructured":"Zou T, Wang SL, Wang N, et al. Correlation of Vancomycin concentration with clinical outcome and nephrotoxicity in elderly patients with deep infection. Chinese J Gerontol. 2022;42(17):4226-4229.","journal-title":"Chinese J Gerontol"},{"issue":"22","key":"e_1_3_4_24_2","first-page":"3867","article-title":"A retrospective evaluation of the ability of SmartDose, an individualized dosing decision support system, to predict Vancomycin steady-state trough concentrations in adults","volume":"34","author":"Zhao LY","year":"2021","unstructured":"Zhao LY, Wu HY, Chen YQ. A retrospective evaluation of the ability of SmartDose, an individualized dosing decision support system, to predict Vancomycin steady-state trough concentrations in adults. 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