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The remaining were divided into 0\u00a0Gy, 1\u00a0Gy, and 2\u00a0Gy groups for CIRT. Energy-spectrum CT scans were performed, and brain tissues were collected for histopathology and western blot Test. Survival rates in each group were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results demonstrated that tumors in the 1\u00a0Gy and 2\u00a0Gy groups decreased at different rates up to 14\u00a0days post-CIRT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Furthermore, compared to pre-CIRT measurements, the energy-spectrum parameters gradually increased in the 0\u00a0Gy group, while they decreased in the 2\u00a0Gy group. Post-CIRT, the Ki-67 proliferation index and the expression levels of vascu-larassociated proteins in tumor tissues were significantly reduced in the 1 and 2\u00a0Gy groups. Additionally, the survival times of tumor-bearing rats were prolonged after CIRT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CIRT effectively restricts tumor cell growth and proliferation, leading to improved survival rates in rats with C6 gliomas. The use of energy-spectrum CT with immunohistochemistry for quantitative detection can actively support the effectiveness of carbon ion radiotherapy in inhibiting tumor proliferation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258251327505","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T23:44:31Z","timestamp":1744760671000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the Validity of Carbon Ion Irradiation for C6 Gliomas in Rats"],"prefix":"10.1177","volume":"23","author":[{"given":"Yufeng","family":"Li","sequence":"first","affiliation":[{"name":"Lanzhou University Second Hospital"},{"name":"Lanzhou University"},{"name":"Lanzhou University Second Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Ta","sequence":"additional","affiliation":[{"name":"Ningbo Medical Center LiHuiLi 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