{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:14:57Z","timestamp":1780517697779,"version":"3.54.1"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-2025-677"],"award-info":[{"award-number":["ORF-2025-677"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the present study, the therapeutic effects of Toosendanin (TSN) against Mycoplasma pneumoniae (MP)-induced pneumonia (MPP) in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design<\/jats:title>\n                    <jats:p>Swiss albino mice were exposed to MP culture for 2 days, causing pneumonia, and then treated with TSN for 3 days. Lung weights, total protein, IgM, C-reactive protein, oxidative stress, and inflammatory cytokines were assessed. Histological alterations were evaluated in lung tissues. Molecular docking analysis was performed to test TSN\u2019s interaction with inflammatory cytokines, including interleukin-1 beta (IL-1\u03b2), interleukin-6 (IL-6), transforming growth factor-beta 1 (TGF-\u03b21), and nuclear factor kappa B (NF-\u03baB) were evaluated targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TSN treatment significantly reduced lung weight by approximately 25% compared to the MP-infected group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). Total protein and C-reactive protein (CRP) levels decreased by 30% and 40%, respectively. Malondialdehyde (MDA), was reduced by 35%, while antioxidant enzyme levels (e.g., SOD, CAT) increased by 20%\u201325%. Pro-inflammatory cytokines such as IL-1\u03b2 and IL-6 were significantly lowered by 40%\u201350%. Histological analysis revealed a marked reduction in inflammatory cell infiltration and alveolar damage scores (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01). Molecular docking confirmed strong binding interactions between IL-1\u03b2, IL-6, TGF-\u03b21, NF-\u03baB and TSN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present findings confirm the beneficial effects of TSN in protecting mice from pneumonia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258251367619","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T23:04:37Z","timestamp":1758236677000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Toosendanin Attenuates\n                    <i>Mycoplasma pneumonia<\/i>\n                    Induced Pneumonia (MPP) in Mice via Inhibiting NF-\u03baB-Mediated Inflammatory Response: In\n                    <i>vivo<\/i>\n                    and\n                    <i>silico<\/i>\n                    Studies"],"prefix":"10.1177","volume":"23","author":[{"given":"Yin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Ankang People\u2019s Hospital, Ankang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyou","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Oncology Intervention, Central Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3851-0585","authenticated-orcid":false,"given":"Cuicui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Yan \u2019an University, Yan \u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A.","family":"Alarfaj","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurahman","family":"Hajinur Hirad","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11112237"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41479-022-00096-z"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030548"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.06.006"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir531"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146377"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(17)30198-6"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01764-w"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S428900"},{"issue":"3","key":"e_1_3_7_11_2","first-page":"288","article-title":"Epidemiology and mechanism of drug resistance of Mycoplasma pneumoniae in Beijing, China: a multicenter study","volume":"19","author":"Guo DX","year":"2019","unstructured":"Guo DX, Hu WJ, Wei R, et al. 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