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(1) Antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)), glutathione (GSH) content, and levels of malondialdehyde (MDA), myeloperoxidase (MPO) in mice serum were measured using commercial kits; (2) The spleen index was calculated; (3) Hematoxylin\u2013eosin (H&amp;E) staining was performed to observe spleen morphology; (4) Splenocyte apoptosis and DNA damage were detected; (5) Immunohistochemistry and Western blotting were employed to detect DNA damage repair (eg, \u03b3-H2AX) and apoptosis-related protein expression in splenic tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LP pretreatment alleviated irradiation-induced impairment of antioxidant capacity in mice, increased SOD, CAT, GPx activities and GSH content, decreased MDA and MPO levels. It reversed irradiation-induced reduction in spleen index. H&amp;E staining showed LP mitigated radiation-caused splenic morphological damage. TUNEL assay demonstrated LP lowered the splenocyte apoptosis rate. Comet assay confirmed LP inhibited radiation-induced DNA damage in splenocytes. Immunohistochemistry and Western blotting results revealed LP down-regulated the expression of \u03b3-H2AX and modulated DNA damage repair-related proteins, regulating apoptosis-related protein levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LP can protect mice from radiation-induced splenic damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258251409856","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T06:45:07Z","timestamp":1766385907000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Radio-Protective Effect of Lanzhou Lily Polysaccharide on the Spleen in Mice"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0850-8306","authenticated-orcid":false,"given":"Zhong","family":"Guo","sequence":"first","affiliation":[{"name":"College of Medicine, Northwest Minzu University"},{"name":"Medical College of Northwest Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Medicine, Northwest Minzu University"},{"name":"Medical College of Northwest Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7167-5086","authenticated-orcid":false,"given":"Lina","family":"Lu","sequence":"additional","affiliation":[{"name":"Northwest Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiu","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Medicine, Northwest Minzu University"},{"name":"Medical College of Northwest Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-063X","authenticated-orcid":false,"given":"Yanqing","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Medicine, Northwest Minzu University"},{"name":"Medical College of Northwest Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[{"name":"College of Medicine, Northwest Minzu University"},{"name":"Medical College of Northwest Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Medicine, Northwest Minzu University"},{"name":"Medical College of Northwest Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2335-0466","authenticated-orcid":false,"given":"Zhiyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Northwest Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,21]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-019-0286-y"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16020"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.3967\/bes2015.019"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","unstructured":"Yi LR Tian M Piao CN et alThe protective effects of 1 2-propanediol against radiation-induced hematopoietic injury in mice. 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