{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:56:37Z","timestamp":1777553797295,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060019"],"award-info":[{"award-number":["82060019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation","award":["2024GXNSFDA010042"],"award-info":[{"award-number":["2024GXNSFDA010042"]}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2024GXNSFBA010244"],"award-info":[{"award-number":["2024GXNSFBA010244"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The present study aimed to compare the dose distributions between conventional three-catheter intracavitary (IC) brachytherapy and combined intracavitary\u2013interstitial (IC\/IS) brachytherapy in the management of locally advanced cervical cancer (LACC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective dosimetric analysis was performed using data from 78 patients with cervical cancer who underwent high-dose-rate (HDR) brachytherapy. To evaluate the dosimetric advantages of IC\/IS brachytherapy, patients were stratified into two groups: those treated with IC brachytherapy and those treated with IC\/IS brachytherapy. Dosimetric parameters between the two groups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the IC\/IS brachytherapy group, V150 values for the high-risk clinical target volume (HR-CTV) were significantly higher than those in the IC group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). Subsequent comparison of organ-at-risk (OAR) dosimetric parameters revealed that D\n                      <jats:sub>0.1<\/jats:sub>\n                      cc, D\n                      <jats:sub>1<\/jats:sub>\n                      cc, D\n                      <jats:sub>2<\/jats:sub>\n                      cc, D\n                      <jats:sub>5<\/jats:sub>\n                      cc, and D\n                      <jats:sub>10<\/jats:sub>\n                      cc values for the bladder and sigmoid colon were significantly lower in the IC\/IS group than in the IC group (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with conventional IC brachytherapy, combined IC\/IS brachytherapy provides superior HR-CTV coverage with higher doses while simultaneously reducing radiation exposure to the bladder and sigmoid colon, provided that the D90 dose constraint for the HR-CTV is met.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258261430575","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:59:01Z","timestamp":1773298741000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric Comparison of Intracavitary Versus Combined Intracavitary-Interstitial Image-Guided Brachytherapy in Locally Advanced Cervical Cancer"],"prefix":"10.1177","volume":"24","author":[{"given":"Xi","family":"Yang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University"},{"name":"Qianhai Life Insurance Guangxi Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guilin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyong","family":"Yu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guilin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuokai","family":"He","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guilin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilian","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guilin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rensheng","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-0395","authenticated-orcid":false,"given":"Kai","family":"Hu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical 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