{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:54:17Z","timestamp":1781502857054,"version":"3.54.1"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Ferroptosis is a distinct form of programmed cell death characterized by iron (Fe)-dependent oxidative stress and the accumulation of intracellular reactive oxygen species. Cisplatin (CPT), a chemotherapeutic agent, can induce ferroptosis in glioma cells and act synergistically with erastin (EST). The total extract of the fungus\n                      <jats:italic toggle=\"yes\">Sanghuangporus vaninii<\/jats:italic>\n                      (TSV) has anticancer and antioxidant activities. This investigation aimed to assess the properties of TSV on CPT-induced inflammatory response and ferroptosis-related changes in glioma cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>LNZ308 glioma cells were exposed to CPT and EST, followed by treatment with different TSV concentrations. Cell viability was assessed. Intracellular reactive oxygen species (ROS), glutathione peroxidase 4 (GPX4), glutathione (GSH), labile iron pool (LIP), LPO, interleukin-1 beta (IL-1\u03b2), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-\u03b1) were examined, and cell migration was assessed using a scratch assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TSV (25 \u00b5g\/mL) exhibited limited toxicity to LNZ308 cells but failed to reverse the CPT-induced loss of cell viability. TSV markedly reduced ROS levels, LIP, and LPO, while restoring GSH and GPX4 levels. Moreover, it diminished IL-1\u03b2, TNF-\u03b1, and IL-6 in CPT-treated LNZ308 cells in a dose-responsive manner. L-ascorbic acid diminished ROS levels during oxidative stress. TSV also promoted scratch closure in both untreated and CPT-treated LNZ308 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results indicate that TSV modulates CPT-induced oxidative, inflammatory, and ferroptotic responses in LNZ308 glioma cells in vitro, supporting further investigation of its potential as an adjunct to chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258261454529","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:35:38Z","timestamp":1781253338000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Total\n                    <i>Sanghuangporus vaninii<\/i>\n                    Extract Ameliorates Cisplatin-Induced Glioma Cell Death by Regulating Ferroptosis and Inflammation"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8688-3146","authenticated-orcid":false,"given":"Yankai","family":"Xu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Shantou University Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiesi","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shantou University Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shantou University Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shantou University Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shantou University Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebin","family":"Xue","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shantou University Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-19176-3.00047-9"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16213653"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02567-3"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2023.2198467"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01782-7"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4BM00043A"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-024-04760-w"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052529"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.47852\/bonviewMEDIN52023816"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/md23040173"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40011-025-01670-3"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117284"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713162"},{"issue":"5","key":"e_1_3_5_15_2","first-page":"4670","article-title":"Echinatin mitigates sevoflurane-induced neurotoxicity through regulation of ferroptosis and iron homeostasis","volume":"16","author":"You Y","year":"2024","unstructured":"You Y, Zhou X, Tang Q, et al. 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