{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T07:05:40Z","timestamp":1779606340110,"version":"3.53.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Science and Technology Department Project of Tibet Autonomous Region","award":["XZ202101ZD0016G"],"award-info":[{"award-number":["XZ202101ZD0016G"]}]},{"name":"The Science and Technology Department Project of Tibet Autonomous Region","award":["XZ202101ZR0076G"],"award-info":[{"award-number":["XZ202101ZR0076G"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Renqing Changjue (RQCJ) is a form of Tibetan medicine recognized for its immunomodulatory effects. However, the underlying mechanisms through which it exerts these effects remain to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We randomly divided 180 male Kunming mice into five groups: control, model (CTX), and high-, medium-, low-dose RQCJ (RQCJH, RQCJM, and RQCJL respectively). The mice received appropriate medications for 15 days. We measured body weight, thymus, spleen index, immune-related cytokines, T cells, and antibodies to evaluate the immunomodulatory effects. Finally, the impact of RQCJ on immunocompromised mice was examined using spleen transcriptome sequencing analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The RQCJ can significantly enhance immune function by regulating specific and non-specific immunity. Transcriptome analysis revealed significant changes in the cytosolic DNA-sensing pathway, TNF signaling pathway, ECM-receptor interactions, and Chagas disease within the RQCJH group. The Jag1 and Tgtp1 genes showed significant upregulation and demonstrated noteworthy correlations with the proportions of T-cell subsets and levels of cytokine expression. Additionally, these genes, along with Rtp4, Irf7, Dhx58, Il1b, Ifi44, and Ifi35 may be the important gene targets for the action of RQCJ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides new insights into the mechanisms by which RQCJ modulates immune responses, offering theoretical foundations for tumor treatment and clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258261454535","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T23:19:39Z","timestamp":1779405579000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Tibetan Medicine Renqing Changjue Extracts on Cyclophosphamide-Induced Immunosuppression in a Mouse Model"],"prefix":"10.1177","volume":"24","author":[{"given":"Zhao","family":"Jiang","sequence":"first","affiliation":[{"name":"Xizang Minzu University"},{"name":"Xizang Minzu University"},{"name":"Ministry of Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Kong","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Xizang Minzu University"},{"name":"Ministry of Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Lv","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Ministry of Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Ministry of Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Ji","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Ministry of Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-2541","authenticated-orcid":false,"given":"Qin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Xizang Minzu University"},{"name":"Ministry of Education"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvad202"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00304-7"},{"key":"e_1_3_4_4_2","volume-title":"Chinese Pharmacopoeia Part 1 S","author":"Chinese Pharmacopoeia Commission","year":"2010","unstructured":"Chinese Pharmacopoeia Commission. Chinese Pharmacopoeia Part 1 S. Beijing: China Medical Science and Technology Press; 2010."},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001-1528.2013.03.054"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.16041\/j.cnki.cn15-1175.2023.03.019"},{"key":"e_1_3_4_7_2","first-page":"21","article-title":"Experimental study of Renqingchangjue combined with cyclophosphamide on treatment for leukemia","volume":"23","author":"Wu HG","year":"2014","unstructured":"Wu HG, Shao CL, Fu SX. Experimental study of Renqingchangjue combined with cyclophosphamide on treatment for leukemia. 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