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Lifestyle, in particular, diet-induced obesity (DIO) is closely linked to cancer risk factors. Most prior studies, however, have concentrated on the impact of long-term lifestyle factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We assessed the impact of a short-term, high-fat diet (HFD) during young or adult on lifespan shortening and tumor development after infant radiation exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>B6C3F1 male mice were irradiated at 1 week of age with 4 Gy of gamma rays or did not undergo irradiation (0 Gy). After weaning, they were assigned to HFD or normal-fat diet (NFD) for four weeks during young (4\u20138 weeks old) or adult (20\u201324 weeks old) stages. Body weight measurement, plasma biochemical analysis, lifespan analysis, and histopathological analysis for tumor diagnosis were carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A temporary gain of body weight and hyperlipidemia were observed in mice fed the HFD. Although short-term HFD intake had limited impact on lifespan shortening and tumor development, a short-term HFD at a young age significantly increased spontaneous hepatocellular carcinoma (HCC) risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The influence of a short-term HFD on DIO-associated cancer, such as HCC, should be specifically noted. Lifestyle normalization has potential for reducing cancer risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258261469760","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:01:12Z","timestamp":1784739672000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of a Short-Term High-Fat Diet on Lifespan and Tumorigenesis After Early-Life Exposure to Radiation"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0048-7682","authenticated-orcid":false,"given":"Yi","family":"Shang","sequence":"first","affiliation":[{"name":"National Institutes for Quantum Science and Technology (QST)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7067-3012","authenticated-orcid":false,"given":"Takamitsu","family":"Morioka","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology (QST)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Amasaki","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology (QST)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2407-953X","authenticated-orcid":false,"given":"Chizuru","family":"Tsuruoka","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology (QST)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-0701","authenticated-orcid":false,"given":"Masaaki","family":"Sunaoshi","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology (QST)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Yanagihara","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology (QST)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Nagasaki University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-8813","authenticated-orcid":false,"given":"Shizuko","family":"Kakinuma","sequence":"additional","affiliation":[{"name":"National Institutes for Quantum Science and Technology (QST)"},{"name":"Institute for Environmental Sciences (IES)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrw005"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60815-0"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-11-201206050-00002"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyac238"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2021.0077"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR2083.1"},{"issue":"7","key":"e_1_3_7_8_2","first-page":"773","article-title":"Lifestyle factors, radiation and gastric cancer in atomic-bomb survivors (Japan)","volume":"16","author":"Sauvaget C","year":"2005","unstructured":"Sauvaget C, Lagarde F, Nagano J, Soda M, Koyama K, Kodama K. 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