{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:17:01Z","timestamp":1788250621859,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Joint Funds for the Innovation Scientific and Technological","award":["2024Y9724"],"award-info":[{"award-number":["2024Y9724"]}]},{"name":"Xiamen Medical College School-Hospital Joint Funding Project","award":["K2023-03"],"award-info":[{"award-number":["K2023-03"]}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J011399"],"award-info":[{"award-number":["2024J011399"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xiamen Medical College Youth Talent Introduction and Cultivation Project","award":["K2023-19"],"award-info":[{"award-number":["K2023-19"]}]},{"DOI":"10.13039\/100016808","name":"Natural Science Foundation of Xiamen Municipality","doi-asserted-by":"crossref","award":["3502Z202372060"],"award-info":[{"award-number":["3502Z202372060"]}],"id":[{"id":"10.13039\/100016808","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Longyan City Science and Technology Plan Project","award":["2023LYF17061"],"award-info":[{"award-number":["2023LYF17061"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the expression pattern, prognostic significance, immune relevance, and biological function of Dynein Light Chain Roadblock-Type 1 (DYNLRB1) in hepatocellular carcinoma (HCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Publicly available datasets and analytical platforms, including TCGA, GTEx, TIMER2.0, TISIDB, LinkedOmics, GEPIA2, CancerSEA, and the Human Protein Atlas, were utilized to evaluate DYNLRB1 expression, prognostic value, and immune infiltration characteristics. In vitro functional assays\u2014including CCK-8, EdU incorporation, colony formation, wound-healing, and Transwell assays\u2014were performed to validate the biological role of DYNLRB1 in HCC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DYNLRB1 was significantly upregulated in HCC tissues and cell lines. Elevated DYNLRB1 expression was consistently associated with advanced clinicopathological features and poor survival outcomes across multiple metrics (including OS, DSS, DFI, and PFI). Furthermore, high DYNLRB1 expression correlated with an immunosuppressive tumor microenvironment signature, characterized by elevated inhibitory immune checkpoints. Functional enrichment suggested involvement in ribosome biogenesis and cell-cycle-associated processes. In vitro, DYNLRB1 knockdown significantly inhibited HCC cell proliferation, migration, and invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DYNLRB1 is a potential prognostic biomarker associated with tumor malignant progression and an immunosuppressive microenvironment in HCC. These findings suggest that DYNLRB1 may represent a potential therapeutic target warranting further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258261473582","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:04:10Z","timestamp":1787997850000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["DYNLRB1: A Potential Prognostic Biomarker Associated With an Immunosuppressive Microenvironment in Hepatocellular Carcinoma"],"prefix":"10.1177","volume":"24","author":[{"given":"Qiaoqiao","family":"Huang","sequence":"first","affiliation":[{"name":"Fujian Province University"},{"name":"Xiamen Medical College"},{"name":"Xiamen Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9891-6924","authenticated-orcid":false,"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Province University"},{"name":"Xiamen Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Province University"},{"name":"Xiamen Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deying","family":"Xiao","sequence":"additional","affiliation":[{"name":"Longyan First Affiliated Hospital of Fujian Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Xie","sequence":"additional","affiliation":[{"name":"Longyan First Affiliated Hospital of Fujian Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Xu","sequence":"additional","affiliation":[{"name":"Fujian Province University"},{"name":"Xiamen Medical College"},{"name":"Xiamen Medical College"},{"name":"Fujian Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.08.021"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915745"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00438-0"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00573-2"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1680"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00704-9"},{"key":"e_1_3_6_10_2","first-page":"109506","article-title":"km23-1\/DYNLRB1 regulation of MEK\/ERK signaling and R-Ras in invasive human colorectal cancer cells","volume":"68","author":"Jin Q","year":"2020","unstructured":"Jin Q, Ding W, Mulder KM. km23-1\/DYNLRB1 regulation of MEK\/ERK signaling and R-Ras in invasive human colorectal cancer cells. 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