{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:13:56Z","timestamp":1788506036904,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Natural Science Project of Education Department of Shaanxi Provincial Government","award":["24JK0684"],"award-info":[{"award-number":["24JK0684"]}]},{"name":"Xizang Minzu University","award":["26MDY30"],"award-info":[{"award-number":["26MDY30"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160165"],"award-info":[{"award-number":["32160165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dose-Response"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acute liver injury, a lethal septic shock complication with scarce treatments, lacks research on Sesamoside\u2019s liver-protective function. We explored its protective mechanisms against lipopolysaccharide (LPS)-induced liver injury via the nuclear factor kappa B\/mitogen-activated protein kinases (NF-\u03baB\/MAPK) pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Tumor necrosis factor-alpha (TNF-\u03b1), interleukin-6 (IL-6), interleukin-1 beta (IL-1\u03b2), and NF-\u03baB\/MAPK pathway were screened via bioinformatic analysis, and an LPS-induced mouse model was established for\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      verification. Quantitative real-time polymerase chain reaction (qPCR) detected cytokines and vasoactive factors; Western blot measured proteins; Hematoxylin and eosin (H&amp;E) staining and Immunohistochemistry (IHC) assessed liver pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      1-, 5-, and 10 mg\/kg Sesamoside suppressed LPS- triggered excess TNF-\u03b1 (\u223c97%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), IL-6 (\u223c95%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), IL-1\u03b2 (\u223c91%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0011) and nitric oxide (NO) (\u223c96%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001). It reduced NOD-like receptor family pyrin domain-containing 3 (NLRP3) by \u223c25% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), and decreased nuclear factor-kappa B p65 subunit (P65), phosphorylated extracellular signal-regulated kinase\/total extracellular signal-regulated kinase (p-ERK\/ERK), phosphorylated c-Jun N-terminal kinase\/total c-Jun N-terminal kinase (p-JNK\/JNK) by 61% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), 25% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0066) and 49% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001) respectively. Liver injury and inflammatory infiltration were markedly attenuated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sesamoside alleviates septic shock-related acute liver injury by inhibiting NF-\u03baB\/MAPK signaling and excessive inflammation, providing a promising natural compound for targeted therapy development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15593258261484434","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:24:25Z","timestamp":1788265465000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sesamoside Alleviates Inflammatory Response in Septic Shock-Associated Acute Liver Injury by Modulating the NF-\u03baB\/MAPK Signaling Pathway"],"prefix":"10.1177","volume":"24","author":[{"given":"Xinjie","family":"Zhao","sequence":"first","affiliation":[{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Hao","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaijie","family":"Wei","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqing","family":"Tian","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-8078","authenticated-orcid":false,"given":"Dan","family":"Song","sequence":"additional","affiliation":[{"name":"Xizang Minzu University"},{"name":"Xizang Minzu University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-02426"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.1100"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-27714-2"},{"issue":"5","key":"e_1_3_4_5_2","first-page":"680","article-title":"Clinical profiles, interventions, and outcomes of sepsis and septic shock in a saudi arabian tertiary icu: a five-year retrospective analysis","volume":"14","author":"Asiri A","year":"2026","unstructured":"Asiri A, Amer KA, Alqahtani M, et al. 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