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This analytic review highlights the critical need to address these risks through a lifestyle medicine approach, advocating for integrated care strategies to mitigate the long-term health impacts of toxic environmental exposures. We explore exposures to environmental toxins in 2 at-risk populations, military service members exposed to airborne hazards and burn pits during overseas deployments and first responders to the World Trade Center terrorist attack. The review highlights the immediate and long-term chronic health effects of toxic environmental exposures, emphasizing the variable symptoms, long latency, and long-term complex outcomes that necessitate an exposure-informed health care model. Exposure-informed care can enhance overall well-being and reduce the risks of chronic illnesses by incorporating lifestyle medicine principles supported by a learning community system. The proposed model makes recommendations for a shift to exposure-informed preventative care. This enhanced approach aims to promote a longer and healthier life for those at increased risks following toxic environmental exposures. Understanding the context of military burn pit and World Trade Center environmental exposures and the possibilities of exposure-informed care is paramount in shifting from a traditional disease-centered model to a holistic, person-centered approach.<\/jats:p>","DOI":"10.1177\/15598276251327106","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T05:56:53Z","timestamp":1742795813000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Exposure-Informed Care Following Toxic Environmental Exposures: A Lifestyle Medicine Approach"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-4835","authenticated-orcid":false,"given":"Pamela K.","family":"Ginex","sequence":"first","affiliation":[{"name":"School of Nursing, State University of New York at Stony Brook, Stony Brook, NY, USA (PKG)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Barach","sequence":"additional","affiliation":[{"name":"College of Population Health, Thomas Jefferson University, Philadelphia, PA, USA (PRB)"},{"name":"Maj (Ret), Medical Corp, Army (PRB)"},{"name":"Department of Surgery, Imperial College London, London, UK (PRB)"},{"name":"Sheps Center for Health Services Research, University of North Carolina, Chapel Hill (PB), North Carolina, USA (PRB)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA (PB)"},{"name":"Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA (PB)"},{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy (PB)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jedidah T.","family":"Poole","sequence":"additional","affiliation":[{"name":"Social, Behavioral, and Population Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA (JP)"},{"name":"Amie Muller Research Program, Burn Pits 360 Veterans Organization, Robstown, TX, USA (JP, JT, TB)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janeen H.","family":"Trembley","sequence":"additional","affiliation":[{"name":"Research Service, Minneapolis Veterans Affairs Health Care Center (MVAHCS), Minneapolis, MN, USA (JHT, TAB)"},{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA (JHT)"},{"name":"Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA (JHT)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Tom\u1ea5\u0161ka","sequence":"additional","affiliation":[{"name":"Amie Muller Research Program, Burn Pits 360 Veterans Organization, Robstown, TX, USA (JP, JT, TB)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Klein","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology Section, Minneapolis VA Healthcare System, Minneapolis, MN, USA (MAK)"},{"name":"Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA (MAK)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy A.","family":"Butterick","sequence":"additional","affiliation":[{"name":"Research Service, Minneapolis Veterans Affairs Health Care Center (MVAHCS), Minneapolis, MN, USA (JHT, TAB)"},{"name":"Research Service, Minneapolis Veterans Affairs Health Care Center (MVAHCS), Minneapolis, MN, USA (TAB)"},{"name":"Department of Neuroscience, University of Minnesota, St Paul, MN, USA (TAB)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202201-0153LE"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21723"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2023.06.007"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1559827619834527"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2020.07.006"},{"key":"e_1_3_4_7_2","volume-title":"Lifestyle Medicine","author":"Rippe JM","year":"1999","unstructured":"Rippe JM. 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