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Historical examples of infectious diseases, such as smallpox, yellow fever, polio, HIV, and COVID-19, illustrate racial mortality differences that were eliminated by removing the diseases. In addition, disparities in cardiovascular death risk factors, including hypertension, type 2 diabetes, inflammation, hyperlipidemia, chronic kidney disease (CKD), and obesity, are examined. The adoption of whole food plant-based (WFPB) diets is proposed as a practical and culturally sensitive solution to mitigate these disparities and promote health equity. 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