{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:10:42Z","timestamp":1777385442248,"version":"3.51.4"},"reference-count":97,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Lifestyle Medicine"],"abstract":"<jats:p>\n                    Healthy dietary interventions are well established in cardiovascular disease prevention, but their effects on the brain remain underexplored. This scoping review aims to investigate how adherence to core components of a whole-food plant-based diet (WFPBD) may impact neuroimaging outcomes across different brain conditions. We searched PubMed and MEDLINE for studies published in the past 20 years evaluating the effects of a predominantly or exclusively WFPBD, alone or combined with other lifestyle factors, on neuroimaging biomarkers. Selected studies were grouped into three domains: (1) demyelinating disease, (2) dementia and Alzheimer\u2019s disease, (3) cognitive aging and cerebrovascular burden. The dataset comprised heterogeneous study designs and follow-up durations, including randomized-controlled trials (RCTs; n\n                    <jats:italic toggle=\"yes\">=<\/jats:italic>\n                    9; 14 days - 3 years), longitudinal observational studies (n\n                    <jats:italic toggle=\"yes\">= 7<\/jats:italic>\n                    ; 2-20 years), and cross-sectional studies (n\n                    <jats:italic toggle=\"yes\">=<\/jats:italic>\n                    6). Observational evidence suggests associations between plant-based dietary patterns and favorable neuroimaging outcomes, whereas RCTs have generally not confirmed these effects. Residual confounding and healthy user bias are potential limitations. Dietary patterns aligned with a WFPBD may be important components of broader lifestyle interventions supporting brain health. Confirming observational findings will require adequately powered randomized trials with standardized neuroimaging endpoints and well-designed dietary interventions.\n                  <\/jats:p>","DOI":"10.1177\/15598276261434176","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:48:40Z","timestamp":1773960520000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Plant-Based Dietary Patterns and Neuroimaging Biomarkers of Brain Health: A Scoping Review of Observational and Interventional Evidence"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6603-7832","authenticated-orcid":false,"given":"Lydia Viviana","family":"Falsitta","sequence":"first","affiliation":[{"name":"University of Toronto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Pikula","sequence":"additional","affiliation":[{"name":"University of Toronto"},{"name":"University Health Network"},{"name":"University Health Network"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9060603"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0606"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.14547"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1138447"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000337301"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01482-z"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13365"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14399"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.12923"},{"key":"e_1_3_8_11_2","volume-title":"PRISMA-Scoping Reviews","author":"PRISMA Executive","year":"2018","unstructured":"PRISMA Executive. 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