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In this context, obesity amplifies risk through inflammation, endothelial dysfunction, and metabolic dysregulation. A life-course approach to prevention identifies preconception health as a critical and actionable window for intervention. Lifestyle medicine, through its core pillars of nutrition, physical activity, sleep, stress management, avoidance of harmful substances, and social connection, offers effective strategies to optimize cardiovascular health before pregnancy. Integrating structured lifestyle interventions into preconception care has the potential to improve maternal outcomes, reduce long-term cardiovascular risk, and promote intergenerational health.<\/jats:p>","DOI":"10.1177\/15598276261471083","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:45:17Z","timestamp":1784785517000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Obesity, Pregnancy, and Cardiovascular Prevention: A Lifestyle Medicine Call to Action for Preconception Health"],"prefix":"10.1177","author":[{"given":"Camilla","family":"Cocchi","sequence":"first","affiliation":[{"name":"Department of Ageing, Orthopedics and Rheumatology, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy (CC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-9530","authenticated-orcid":false,"given":"Anna Vittoria","family":"Mattioli","sequence":"additional","affiliation":[{"name":"University of Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf193"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001124"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579420001121"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000001557"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/2633494120986544"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14777"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1681766"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12092129"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.052"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2025.101054"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00021.2014"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140036"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030598"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu17233731"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2025.10.029"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells15040366"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1667222"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14861"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2026.03.027"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.055772"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.11.001"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14217516"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2024.102695"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022837"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf862"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015123"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","unstructured":"Miller C. 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