{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:21:14Z","timestamp":1792614074880,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Lifestyle Medicine"],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Polyendocrine metabolic ovarian syndrome (PMOS) is a prevalent endocrine disorder affecting 10-13% of reproductive-aged women. Characterized by hyperandrogenism, ovulatory dysfunction, and metabolic disturbances, its management is increasingly focused on the gut-brain-ovary axis and chronic low-grade inflammation. This review examines current evidence for lifestyle-based, nutritional, and pharmacologic interventions in PMOS management.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A review of current literature and clinical guidelines was conducted, focusing on pathophysiology, including genetic, hormonal, and inflammatory drivers, and therapeutic strategies.\n                    <jats:bold>Results:<\/jats:bold>\n                    Lifestyle modification remains the primary therapy, improving insulin sensitivity, menstrual regularity, and psychological well-being. Pharmacologic adjuncts like metformin and oral contraceptives address specific metabolic and reproductive symptoms. Nutritional supplementation, particularly a 40:1 ratio of myo-inositol to D-chiro-inositol, shows significant efficacy in restoring ovarian function. Emerging research highlights the role of gut dysbiosis in driving systemic inflammation and hormonal dysregulation.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Effective PMOS management requires an individualized, multimodal approach that integrates lifestyle medicine with targeted supplementation and pharmacotherapy to address the complex metabolic and reproductive features of the syndrome.\n                  <\/jats:p>","DOI":"10.1177\/15598276261478047","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T02:38:25Z","timestamp":1786934305000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Polyendocrine Metabolic Ovarian Syndrome: A Brief Review"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5800-1044","authenticated-orcid":false,"given":"Samia","family":"Bennani","sequence":"first","affiliation":[{"name":"HCA Healthcare Lee\u2019s Summit Family Medicine Residency Program, Lee's Summit, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Foote","sequence":"additional","affiliation":[{"name":"HCA Healthcare Lee\u2019s Summit Family Medicine Residency Program, Lee's Summit, MO, 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