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As is often the case, the relationship between B vitamin supplementation and improved pregnancy outcomes is more complicated than initially perceived, as the interaction between nutritional factors and selected genes must be considered. In this review, we attempt to summarize the complex clinical and experimental literature on nutritional factors, their biological transport mechanisms, and interactions with genetic polymorphisms that impact early embryogenesis. While not exhaustive, our goal was to provide an overview of important gene\u2013nutrient interactions, focusing on folic acid and vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    , to serve as a framework for understanding the multiple roles they play in early embryogenesis.\n                  <\/jats:p>","DOI":"10.1177\/15648265080292s112","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T16:07:40Z","timestamp":1448467660000},"page":"S86-S98","source":"Crossref","is-referenced-by-count":21,"title":["Gene\u2013Nutrient Interactions: Importance of Folic Acid and Vitamin B\n                    <sub>12<\/sub>\n                    During Early Embryogenesis"],"prefix":"10.1177","volume":"29","author":[{"given":"Richard H.","family":"Finnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary 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