{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:36:42Z","timestamp":1793497002299,"version":"4.5.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"2_suppl1","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Food Nutr Bull"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>\n                    Folate deficiency in the periconceptional period contributes to neural tube defects; deficits in vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    (cobalamin) have negative consequences on the developing brain during infancy; and deficits of both vitamins are associated with a greater risk of depression during adulthood. This review examines two mechanisms linking folate and vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency to abnormal behavior and development in infants: disruptions to myelination and inflammatory processes. Future investigations should focus on the relationship between the timing of deficient and marginal vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    status and outcomes such as infant growth, cognition, social development, and depressive symptoms, along with prevention of folate and vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency.\n                  <\/jats:p>","DOI":"10.1177\/15648265080292s117","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T16:07:40Z","timestamp":1448467660000},"page":"S126-S131","source":"Crossref","is-referenced-by-count":366,"title":["Effects of Vitamin B\n                    <sub>12<\/sub>\n                    and Folate Deficiency on Brain Development in Children"],"prefix":"10.1177","volume":"29","author":[{"given":"Maureen 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